Equation 2-(all-trans-octaprenyl)phenol + prephenate + oxidized electron carrier + H+ → 3-(all-trans-octaprenyl)benzene-1,2-diol + 3-phenyl-2-oxopropanoate + CO2 + reduced two electron carrier
Note that this reaction equation differs from the official Enzyme Commission reaction equations for this EC entry, which can be found , and .
Enzymes and Genes
Pathway

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the for more information.

BioCyc IdRXN-24716
Mass Balance StatusBalanced.
Direction NoteThe reaction direction shown is in accordance with the direction in which it was curated.
EC Number 1.97.1.15 -- 2-(all-trans-polyprenyl)phenol 6-hydroxylase (prephenate)
Enzyme Commission Synonyms ubiquinone hydroxylase UbiUV
Generic Reaction

Enzyme Commission Summary

The enzyme, characterized from the bacterium , catalyzes three hydroxylation reactions in the oxygen-independent pathway for ubiquinone (UQ) biosynthesis. The reaction involves an electron acceptor whose identity remains unknown as of 2024. The enzyme is a heterodimer, with both subunits containing a 4Fe-4S iron-sulfur cluster that is essential for activity and may serve as part of an electron transfer chain from the substrate to the unidentified electron acceptor.

Citations: [, , ]

BRENDA Ec1.97.1.15
ENZYME Ec1.97.1.15
IUBMB-ExplorEnz Ec1.97.1.15

Gene-Reaction Schematic

Credits:
Created 05-Aug-2024 by Caspi R, SRI International