Equation an [eIF5A-precursor]-deoxyhypusine + reduced two electron carrier + dioxygen → an [eIF5A]-hypusine + oxidized electron carrier + H2O
Enzymes and Genes
Pathway

Show Atom Mapping (Computed):

BioCyc IdDEOXYHYPUSINE-MONOOXYGENASE-RXN
Mass Balance StatusBalanced.
Direction NoteThe reaction direction shown is in accordance with the direction in which it was curated.
EC Number 1.14.99.29 -- deoxyhypusine monooxygenase
Enzyme Commission Synonyms deoxyhypusine hydroxylase
deoxyhypusine dioxygenase

Enzyme Commission Summary

Catalyzes the final step in the formation of the amino acid hypusine in eukaryotic initiation factor 5A (eIF-5A) (formerly eIF-4D).

KEGG reactionR04437
METANETXMNXR115823
RHEA14102

BRENDA Ec1.14.99.29
ENZYME Ec1.14.99.29
IUBMB-ExplorEnz Ec1.14.99.29

Gene-Reaction Schematic