Parent Class:

EC-Numbers → 7 -- Translocases → 7.4 -- Catalysing the translocation amino acids and peptides → 7.4.2 -- Linked to the hydrolysis of a nucleoside triphosphate

Synonyms: glutathione transporting ATPase, gsiACD, glutathione ABC transporter

Systematic Name: ATP phosphohydrolase (ABC-type,glutathione-importing)

Unification Links: BRENDA:7.4.2.10, ENZYME:7.4.2.10, IUBMB-ExplorEnz:7.4.2.10

Reaction:
glutathione_[periplasm] + ATP + H₂O → glutathione_[cytosol] + ADP + phosphate + H⁺

Enzymes and Genes:
glutathione ABC transporter: gsiC, gsiD, gsiB, gsiA ( Escherichia coli K-12 substr. MG1655 )

Summary:
ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. The enzyme from Escherichia coli is a heterotrimeric complex that interacts with an extracytoplasmic substrate binding protein to mediate the uptake of glutathione.

Citations: [Suzuki05a, Moussatova08]

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References

Moussatova08: Moussatova A, Kandt C, O'Mara ML, Tieleman DP (2008). "ATP-binding cassette transporters in Escherichia coli." Biochim Biophys Acta 1778(9);1757-71. PMID: 18634750

Suzuki05a: Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H (2005). "The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette." J Bacteriol 187(17);5861-7. PMID: 16109926

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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