hide
show operations
| Parent Class: | EC-Numbers → 4 -- Lyases → 4.2 -- Carbon-oxygen lyases → 4.2.1 -- Hydro-lyases |
Synonyms: (6S)-β-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase(ADP-hydrolysing), (6S)-6-β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing, NADH-forming)
Systematic Name: (6S)-6β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ADP-hydrolysing; NADH-forming)
Unification Links: BRENDA:4.2.1.136, ENZYME:4.2.1.136, IUBMB-ExplorEnz:4.2.1.136
Reaction:
(S)-NADPHX + ADP → AMP + NADPH + phosphate + H+,
(S)-NADHX + ADP → AMP + NADH + phosphate + H+
Enzymes and Genes:
NAD(P)HX epimerase / NAD(P)HX dehydratase:
nnr (
Escherichia coli K-12 substr. MG1655
)
Summary:
Acts equally well on hydrated NADH and hydrated NADPH. NAD(P)H spontaneously hydrates to both the (6S)- and (6R)- isomers. The enzyme from bacteria consists of two domains, one of which acts as an NAD(P)H-hydrate epimerase that interconverts the two isomers to a 60:40 ratio (c.f.
EC 5.1.99.6), while the other catalyses the dehydration. Hence the enzyme can restore the complete mixture of isomers into NAD(P)H. The enzyme has no activity with ATP, contrary to the enzyme from eukaryotes (cf.
EC 4.2.1.93, ATP-dependent NAD(P)H-hydrate dehydratase).
Citations: [Marbaix11]
References
Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 29.0 (software by SRI International) on Sun Apr 13, 2025, BIOCYC15A.
