MetaCyc EC 4.1.1.87 -- malonyl-[malonate decarboxylase] decarboxylase

Parent Class: EC-Numbers → 4 -- Lyases → 4.1 -- Carbon-carbon lyases → 4.1.1 -- Carboxy-lyases

Synonyms: malonyl-S-acyl-carrier protein decarboxylase, MdcD/MdcE, MdcD,E, malonyl-S-ACP decarboxylase

Systematic Name: malonyl-[acyl-carrier-protein] carboxy-lyase

Unification Links: BRENDA:4.1.1.87, ENZYME:4.1.1.87, IUBMB-ExplorEnz:4.1.1.87

Reaction:
malonyl-[holo malonate decarboxylase acyl-carrier protein] + H+ → acetyl-[holo malonate decarboxylase acyl-carrier protein] + CO2

Enzymes and Genes:
malonate decarboxylase: mdcE, mdcD ( Klebsiella pneumoniae )

Summary:
This enzyme comprises the β and γ subunits of EC 4.1.1.88, biotin-independent malonate decarboxylase, but is not present in EC 7.2.4.4, biotin-dependent malonate decarboxylase. It follows on from EC 2.3.1.187, acetyl-S-ACP:malonate ACP transferase, and results in the regeneration of the acetylated form of the acyl-carrier-protein subunit of malonate decarboxylase [Dimroth97]. The carboxy group is lost with retention of configuration [Handa99].

Citations: [Schmid96, Koo99, Chohnan03]

References

Chohnan03: Chohnan S, Akagi K, Takamura Y (2003). "Functions of malonate decarboxylase subunits from Pseudomonas putida." Biosci Biotechnol Biochem 67(1);214-7. PMID: 12619701

Dimroth97: Dimroth P, Hilbi H (1997). "Enzymic and genetic basis for bacterial growth on malonate." Mol Microbiol 25(1);3-10. PMID: 11902724

Handa99: Handa S, Koo JH, Kim YS, Floss HG (1999). "Stereochemical course of biotin-independent malonate decarboxylase catalysis." Arch Biochem Biophys 370(1);93-6. PMID: 10496981

Koo99: Koo JH, Kim YS (1999). "Functional evaluation of the genes involved in malonate decarboxylation by Acinetobacter calcoaceticus." Eur J Biochem 266(2);683-90. PMID: 10561613

Schmid96: Schmid M, Berg M, Hilbi H, Dimroth P (1996). "Malonate decarboxylase of Klebsiella pneumoniae catalyses the turnover of acetyl and malonyl thioester residues on a coenzyme-A-like prosthetic group." Eur J Biochem 237(1);221-8. PMID: 8620876

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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