Parent Class:

EC-Numbers → 4 -- Lyases → 4.1 -- Carbon-carbon lyases → 4.1.1 -- Carboxy-lyases

Synonyms: 5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase, 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase, 5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)

Systematic Name: (3E,5R)-5-carboxy-2-oxohept-3-enedioate carboxy-lyase [(4Z)-2-oxohept-4-enedioate-forming]

Unification Links: BRENDA:4.1.1.68, ENZYME:4.1.1.68, IUBMB-ExplorEnz:4.1.1.68

Reaction:
(3E,5R)-5-carboxy-2-oxohept-3-enedioate + H⁺ → (4Z)-2-oxohept-4-enedioate + CO₂

Enzymes and Genes:
5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase: hpaG ( Escherichia coli W )

Summary:
Requires Mg²⁺. Part of the (4-hydroxyphenyl)acetate degradation pathway in Escherichia coli C.

Citations: [GarridoPeritier81, Johnson92, Johnson95a]

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References

GarridoPeritier81: Garrido-Peritierra A, Cooper RA (1981). "Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli." Eur J Biochem 1981;117(3);581-4. PMID: 7026235

Johnson92: Johnson WH, Hajipour G, Whitman CP (1992). "Characterization of a dienol intermediate in the 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase reaction." Journal of the American Chemical Society 114(27);11001-11003.

Johnson95a: Johnson WH, Hajipour G, Whitman CP (1995). "Stereochemical Studies of 5-(Carboxymethyl)-2-hydroxymuconate Isomerase and 5-(Carboxymethyl)-2-oxo-3-hexene-1,6-dioate Decarboxylase from Escherichia coli C: Mechanistic and Evolutionary Implications." Journal of the American Chemical Society 117(34);8719-8726.

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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