Parent Class:

EC-Numbers → 2 -- Transferases → 2.7 -- Transferring phosphorous-containing groups → 2.7.1 -- Phosphotransferases with an alcohol group as acceptor

Synonyms: gatABC (gene names), galactitol PTS permease, EII^Gat, Enzyme II^Gat

Systematic Name: protein-N^π-phospho-L-histidine:galactitol N^π-phosphotransferase

Unification Links: BRENDA:2.7.1.200, ENZYME:2.7.1.200, IUBMB-ExplorEnz:2.7.1.200

Supersedes EC number: 2.7.1.69

Reaction:
an [HPr protein]-N^π-phospho-L-histidine + galactitol_[periplasm] → galactitol 1-phosphate_[cytosol] + an [HPr]-L-histidine

Enzymes and Genes:
galactitol-specific PTS enzyme II: gatA, gatB, gatC ( Escherichia coli EC3132 )

Summary:
Enzyme II of the galactitol-specific phosphotransferase system, a member of the superfamily of phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system (PTS). This bacterial enzyme takes up an extracellular substrate and simultaneously phosphorylates it and transports it into the cytoplasm. The phosphate donor is a phospho-carrier protein of low molecular mass (9.5 kDa) that has been phosphorylated by EC 2.7.3.9, phosphoenolpyruvate—protein phosphotransferase. The reaction involves a successive transfer of the phosphate group to several amino acids within the enzyme before the final transfer to the substrate.

Citations: [Nobelmann95, Nobelmann96]

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References

Nobelmann95: Nobelmann B, Lengeler JW (1995). "Sequence of the gat operon for galactitol utilization from a wild-type strain EC3132 of Escherichia coli." Biochim Biophys Acta 1262(1);69-72. PMID: 7772602

Nobelmann96: Nobelmann B, Lengeler JW (1996). "Molecular analysis of the gat genes from Escherichia coli and of their roles in galactitol transport and metabolism." J Bacteriol 178(23);6790-5. PMID: 8955298

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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