Parent Class:

EC-Numbers → 2 -- Transferases → 2.7 -- Transferring phosphorous-containing groups → 2.7.1 -- Phosphotransferases with an alcohol group as acceptor

Synonyms: flavin transferase, apbE (gene name)

Systematic Name: FAD:protein riboflavin-5′-phosphate transferase

Unification Links: BRENDA:2.7.1.180, ENZYME:2.7.1.180, IUBMB-ExplorEnz:2.7.1.180

Reaction:
FAD_[periplasm] + a [protein]-L-threonine_[periplasm] → a [protein]-FMN-L-threonine_[periplasm] + AMP_[periplasm]

Enzymes and Genes:
FAD:protein FMN transferase: ftp ( Escherichia coli K-12 substr. MG1655 )
flavin transferase: apbE ( Vibrio cholerae )

Summary:
The enzyme catalyses the transfer of the FMN portion of FAD and its covalent binding to the hydroxyl group of an L-threonine residue in a target flavin-binding protein such as the B and C subunits of EC 7.2.1.1, NADH:ubiquinone reductase (Na⁺-transporting). Requires Mg²⁺.

Citations: [Bertsova13]

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References

Bertsova13: Bertsova YV, Fadeeva MS, Kostyrko VA, Serebryakova MV, Baykov AA, Bogachev AV (2013). "Alternative pyrimidine biosynthesis protein ApbE is a flavin transferase catalyzing covalent attachment of FMN to a threonine residue in bacterial flavoproteins." J Biol Chem 288(20);14276-86. PMID: 23558683

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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