MetaCyc EC 2.5.1.144 -- S-sulfo-L-cysteine synthase (O-acetyl-L-serine-dependent)

Parent Class: EC-Numbers2 -- Transferases2.5 -- Transferring alkyl or aryl groups, other than methyl groups2.5.1 -- Transferring alkyl or aryl groups, other than methyl groups

Synonyms: cysteine synthase B, cysM (gene name), CS26 (gene name)

Systematic Name: O-acetyl-L-serine:thiosulfate 2-amino-2-carboxyethyltransferase

Unification Links: BRENDA:2.5.1.144, ENZYME:2.5.1.144, IUBMB-ExplorEnz:2.5.1.144

Reaction:
O-acetyl-L-serine + thiosulfate ↔ S-sulfo-L-cysteine + acetate + H+

Enzymes and Genes:
cysteine synthase B: cysM ( Escherichia coli K-12 substr. MG1655 )
S-sulfocysteine synthase: CS26 ( Arabidopsis thaliana )

Summary:
In plants, the activity is catalyzed by a chloroplastic enzyme that plays an important role in chloroplast function and is essential for light-dependent redox regulation within the chloroplast. The bacterial enzyme also catalyses the activity of EC 2.5.1.47, cysteine synthase. cf EC 2.8.5.1, S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent).

Citations: [Hensel83a, Nakamura84, Saito93, Bermudez12, Gotor13]


References

Bermudez12: Bermudez MA, Galmes J, Moreno I, Mullineaux PM, Gotor C, Romero LC (2012). "Photosynthetic adaptation to length of day is dependent on S-sulfocysteine synthase activity in the thylakoid lumen." Plant Physiol 160(1);274-88. PMID: 22829322

Gotor13: Gotor C, Romero LC (2013). "S-sulfocysteine synthase function in sensing chloroplast redox status." Plant Signal Behav 8(3);e23313. PMID: 23333972

Hensel83a: Hensel G, Truper HG (1983). "O-Acetylserine sulfhydrylase and S-sulfocysteine synthase activities of Rhodospirillum tenue." Arch Microbiol 134(3);227-32. PMID: 6615127

Nakamura84: Nakamura T, Iwahashi H, Eguchi Y (1984). "Enzymatic proof for the identity of the S-sulfocysteine synthase and cysteine synthase B of Salmonella typhimurium." J Bacteriol 1984;158(3);1122-7. PMID: 6373737

Saito93: Saito K, Tatsuguchi K, Murakoshi I, Hirano H (1993). "cDNA cloning and expression of cysteine synthase B localized in chloroplasts of Spinacia oleracea." FEBS Lett 324(3);247-52. PMID: 8405359


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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