Parent Class:

EC-Numbers → 2 -- Transferases → 2.5 -- Transferring alkyl or aryl groups, other than methyl groups → 2.5.1 -- Transferring alkyl or aryl groups, other than methyl groups

Synonyms: ubiX (gene name), PAD1 (gene name)

Systematic Name: prenyl-phosphate:FMNH₂ prenyltransferase

Unification Links: BRENDA:2.5.1.129, ENZYME:2.5.1.129, IUBMB-ExplorEnz:2.5.1.129

Reaction:
prenyl phosphate + FMNH₂ → prenylated FMNH₂ + phosphate

Enzymes and Genes:
flavin prenyltransferase: ubiX ( Escherichia coli K-12 substr. MG1655 )
flavin prenyltransferase: ubiX ( Synechocystis sp. PCC 6803 )
flavin prenyltransferase: ubiX ( Pseudomonas aeruginosa )
flavin prenyltransferase: PAD1 ( Saccharomyces cerevisiae )

Summary:
The enzyme produces the modified flavin cofactor prenylated FMNH2, which is required by EC 4.1.1.98, 4-hydroxy-3-polyprenylbenzoate decarboxylase, and EC 4.1.1.102, phenacrylate decarboxylase. The enzyme acts as a flavin prenyltransferase, linking a prenyl moiety to the flavin N5 and C6 atoms and thus adding a fourth non-aromatic ring to the flavin isoalloxazine group.

Citations: [White15]

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References

White15: White MD, Payne KA, Fisher K, Marshall SA, Parker D, Rattray NJ, Trivedi DK, Goodacre R, Rigby SE, Scrutton NS, Hay S, Leys D (2015). "UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis." Nature 522(7557);502-6. PMID: 26083743

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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