Parent Class:

EC-Numbers → 2 -- Transferases → 2.3 -- Acyltransferases → 2.3.1 -- Transferring groups other than amino-acyl groups

Synonyms: papA1 (gene name)

Systematic Name: (hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase]:2′-acyl-2-O-sulfo-α,α-trehalose 3′-(hydroxy)phthioceranyltransferase

Unification Links: BRENDA:2.3.1.283, ENZYME:2.3.1.283, IUBMB-ExplorEnz:2.3.1.283

Reaction:
(hydroxy)phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 2'-palmitoyl/stearoyl-2-O-sulfo-α,α-trehalose → a 3'-(hydroxy)phthioceranyl-2'-palmitoyl(stearoyl)-2-O-sulfo-α,α-trehalose + holo-[(hydroxy)phthioceranic acid synthase]

Unofficial Reactions:
C37-hydroxyphthioceranyl-[(hydroxy)phthioceranic acid synthase] + 2'-palmitoyl-2-O-sulfo-α,α-trehalose → SL₁₂₇₈ + holo-[(hydroxy)phthioceranic acid synthase]

Enzymes and Genes:
2'-n-acyl-2-O-sulfo-trehalose (hydroxy)phthioceranyltransferase: papA1 ( Mycobacterium tuberculosis H37Rv )

Summary:
This mycobacterial enzyme catalyzes the acylation of 2'-palmitoyl/stearoyl-2-O-sulfo-α,α-trehalose at the 3' position by a (hydroxy)phthioceranoyl group during the biosynthesis of sulfolipids.

Citations: [Bhatt07, Kumar07]

---

References

Bhatt07: Bhatt K, Gurcha SS, Bhatt A, Besra GS, Jacobs WR (2007). "Two polyketide-synthase-associated acyltransferases are required for sulfolipid biosynthesis in Mycobacterium tuberculosis." Microbiology 153(Pt 2);513-20. PMID: 17259623

Kumar07: Kumar P, Schelle MW, Jain M, Lin FL, Petzold CJ, Leavell MD, Leary JA, Cox JS, Bertozzi CR (2007). "PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1." Proc Natl Acad Sci U S A 104(27);11221-6. PMID: 17592143

---

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 28.5 (software by SRI International) on Tue Apr 8, 2025, BIOCYC17B.