Parent Class:

EC-Numbers → 2 -- Transferases → 2.3 -- Acyltransferases → 2.3.1 -- Transferring groups other than amino-acyl groups

Synonyms: ablB (gene name)

Systematic Name: acetyl-CoA:(3S)-3,6-diaminohexanoate N⁶-acetyltransferase

Unification Links: BRENDA:2.3.1.264, ENZYME:2.3.1.264, IUBMB-ExplorEnz:2.3.1.264

Reaction:
acetyl-CoA + L-β-lysine → N6-acetyl-L-β-lysine + coenzyme A + H⁺

Enzymes and Genes:
β-lysine N6-acetyltransferase: ablB ( Methanococcus maripaludis )

Summary:
The enzyme isfound in some methanogenic archaea and bacteria. In archaea it is uinduced under salt stress. The product, N6-acetyl-L-β-lysine, serves as a compatible solute, conferring high salt resistance on the producing organisms.

Citations: [Pfluger03, Muller11]

---

References

Muller11: Muller S, Hoffmann T, Santos H, Saum SH, Bremer E, Muller V (2011). "Bacterial abl-like genes: production of the archaeal osmolyte N(ε)-acetyl-β-lysine by homologous overexpression of the yodP-kamA genes in Bacillus subtilis." Appl Microbiol Biotechnol 91(3);689-97. PMID: 21538109

Pfluger03: Pfluger K, Baumann S, Gottschalk G, Lin W, Santos H, Muller V (2003). "Lysine-2,3-aminomutase and beta-lysine acetyltransferase genes of methanogenic archaea are salt induced and are essential for the biosynthesis of Nepsilon-acetyl-beta-lysine and growth at high salinity." Appl Environ Microbiol 69(10);6047-55. PMID: 14532061

---

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 29.0 (software by SRI International) on Sat Apr 12, 2025, BIOCYC17A.