Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.3 -- Acting on the CH-CH group of donors → 1.3.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: geranylgeranyl-bacteriopheophytin reductase, bchP (gene name)

Systematic Name: bacteriochlorophyll-a:NADP⁺ oxidoreductase (geranylgeranyl-reducing)

Unification Links: BRENDA:1.3.1.111, ENZYME:1.3.1.111, IUBMB-ExplorEnz:1.3.1.111

Reaction:
bacteriochlorophyll a + 3 NADP⁺ ← geranylgeranyl bacteriochlorophyllide a + 3 NADPH + 3 H⁺

Unofficial Reactions:
bacteriochlorophyll b + 3 NADP⁺ ← geranylgeranyl bacteriochlorophyllide b + 3 NADPH + 3 H⁺,
bacteriopheophytin a + 3 NADP⁺ ← geranylgeranyl bacteriopheophytin + 3 NADPH + 3 H⁺

Enzymes and Genes:
geranylgeranyl-bacteriochlorophyll a reductase: bchP ( Rhodobacter capsulatus )

Summary:
The enzyme catalyzes the successive reduction of the geranylgeranyl esterifying group to phytyl, reducing three out of four double bonds, and transforming geranylgeranyl bacteriochlorophyllide a via phyta-2,10,14-trienyl bacteriochlorophyllide a and phyta-2,14-dienyl bacteriochlorophyllide a to bacteriochlorophyll a. The enzyme can also accept the pheophytin derivative geranylgeranyl bacteriopheophytin, converting it to bacteriopheophytin a.

Citations: [Bollivar94, Addlesee99, Addlesee02]

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References

Addlesee02: Addlesee HA, Hunter CN (2002). "Rhodospirillum rubrum possesses a variant of the bchP gene, encoding geranylgeranyl-bacteriopheophytin reductase." J Bacteriol 184(6);1578-86. PMID: 11872709

Addlesee99: Addlesee HA, Hunter CN (1999). "Physical mapping and functional assignment of the geranylgeranyl-bacteriochlorophyll reductase gene, bchP, of Rhodobacter sphaeroides." J Bacteriol 181(23);7248-55. PMID: 10572128

Bollivar94: Bollivar DW, Wang S, Allen JP, Bauer CE (1994). "Molecular genetic analysis of terminal steps in bacteriochlorophyll a biosynthesis: characterization of a Rhodobacter capsulatus strain that synthesizes geranylgeraniol-esterified bacteriochlorophyll a." Biochemistry 33(43);12763-8. PMID: 7947681

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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