Parent Class:

EC-Numbers → 1 -- Oxidoreductases → 1.1 -- Acting on the CH-OH group of donors → 1.1.1 -- With NAD(+) or NADP(+) as acceptor

Synonyms: apnO (gene name)

Systematic Name: D-apionate:NAD⁺ oxidoreductase (isomerizing)

Unification Links: BRENDA:1.1.1.421, ENZYME:1.1.1.421, IUBMB-ExplorEnz:1.1.1.421

Reaction:
D-apionate + NAD⁺ → 3-oxoisoapionate + NADH + H⁺

Enzymes and Genes:
D-apionate oxidoisomerase: apnO ( Rhizobium rhizogenes K84 )
D-apionate oxidoisomerase: apnO ( Cupriavidus necator N-1 )
D-apionate oxidoisomerase: apnO ( Pectobacterium atrosepticum SCRI1043 )

Summary:
The enzyme, characterized from several bacterial species, participates in the degradation of D-apionate. The reaction involves migration of a hydroxymethyl group from position 3 to position 2 and oxidation of the 3-hydroxyl group.

Citations: [Carter18]

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References

Carter18: Carter MS, Zhang X, Huang H, Bouvier JT, Francisco BS, Vetting MW, Al-Obaidi N, Bonanno JB, Ghosh A, Zallot RG, Andersen HM, Almo SC, Gerlt JA (2018). "Functional assignment of multiple catabolic pathways for D-apiose." Nat Chem Biol 14(7);696-705. PMID: 29867142

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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