Current and Filled Pathway Holes of <i>Bacteroides ovatus</i> ATCC 8483

Current and Filled Pathway Holes of Bacteroides ovatus ATCC 8483

A pathway hole is a pathway reaction for which no corresponding enzyme has been identified in the genome. We consider only contiguous pathways (pathways containing connected sets of reactions, as opposed to pathways containing unconnected sets of reactions) when enumerating pathway holes.

This report includes two tables regarding pathway holes in Bacteroides ovatus ATCC 8483:

Current Pathway Holes: A list of reactions within metabolic pathways of Bacteroides ovatus ATCC 8483 for which no corresponding enzyme has been found.

Filled Pathway Holes: A list of former pathway holes within metabolic pathways of Bacteroides ovatus ATCC 8483 which have been filled with the assistance of the Pathway Hole Filler.


Current Pathway Holes

This table lists reactions within metabolic pathways of Bacteroides ovatus ATCC 8483 for which no corresponding enzyme has been identified in the genome. The presence of those enzymes is suggested by the presence of the pathway.

101 pathway holes (18.6%) are present in the 542 total reactions of 175 pathways

Reaction EC# Pathway(s) needing this reaction
(S)-malate + NADP+ → CO2 + pyruvate + NADPH 1.1.1.40 gluconeogenesis I
a chitodextrin + n H2O → n N,N'-diacetylchitobiose + N,N',N''-triacetylchitotriose 3.2.1.202 chitin degradation II (Vibrio)
chitin + H2O → 2 a chitodextrin 3.2.1.14 chitin degradation II (Vibrio)
thiamine phosphate + H2O → thiamine + phosphate 3.1.3.100 thiamine diphosphate biosynthesis III (Staphylococcus)
(S)-3-methyl-2-oxopentanoate + coenzyme A + 2 oxidized ferredoxin [iron-sulfur] cluster ↔ 2-methylbutanoyl-CoA + CO2 + 2 reduced ferredoxin [iron-sulfur] cluster + H+ 1.2.7.7 L-isoleucine biosynthesis V
(7Z)-tetradec-7-enoyl-[acp] + NAD+ ← (2E,7Z)-tetradeca-2,7-dienoyl-[acp] + NADH + H+ 1.3.1.9 palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)
palmitoleoyl-[acp] + NAD+ ← (2E,9Z)-hexadeca-2,9-dienoyl-[acp] + NADH + H+ 1.3.1.9 palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)
dermatan sulfate(n) → dermatan sulfate(n-1) + 4-deoxy-β-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate 4.2.2.21 dermatan sulfate degradation I (bacterial)
4-deoxy-β-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate + H2O → 4-deoxy-β-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + sulfate + H+ 3.1.6.9 dermatan sulfate degradation I (bacterial)
α-L-fucopyranose ← β-L-fucopyranose 5.1.3.29 fucose degradation
L-fuculose + ATP → L-fuculose 1-phosphate + ADP + H+ 2.7.1.51 fucose degradation
L-fuculose 1-phosphate → (S)-lactaldehyde + glycerone phosphate 4.1.2.17 fucose degradation
D-mannonate + NAD+ ← D-fructuronate + NADH + H+ 1.1.1.57 D-fructuronate degradation
oxidized thioredoxin + reduced two electron carrier ← reduced thioredoxin + oxidized electron carrier [none] thioredoxin pathway
phosphoenolpyruvate + D-erythrose 4-phosphate + H2O → 3-deoxy-D-arabino-heptulosonate 7-phosphate + phosphate 2.5.1.54 3-dehydroquinate biosynthesis I
[chaperone-ADP]-[disordered-form scaffold protein] complex + ATP → [Fe-S cluster biosynthesis chaperone]-ATP + [disordered-form [Fe-S] cluster scaffold protein] + ADP 3.6.4.- [2Fe-2S] iron-sulfur cluster biosynthesis
[chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex + apo-iron-sulfur protein → [chaperone-ADP]-[disordered-form scaffold protein] complex + [Fe-S cluster biosynthesis co-chaperone] + holo-[2Fe-2S] cluster protein + phosphate [none] [2Fe-2S] iron-sulfur cluster biosynthesis
[co-chaperone]-[scaffold protein-(2Fe-2S)] complex + [Fe-S cluster biosynthesis chaperone]-ATP → [chaperone-ATP]-[co-chaperone]-[scaffold protein-(2Fe-2S)] complex [none] [2Fe-2S] iron-sulfur cluster biosynthesis
[cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex + [Fe-S cluster biosynthesis co-chaperone] → [co-chaperone]-[scaffold protein-(2Fe-2S)] complex + [L-cysteine desulfurase] [none] [2Fe-2S] iron-sulfur cluster biosynthesis
[cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex + 2 Fe3+ → [cysteine desulfurase]-[scaffold protein-(2Fe-2S)] complex [none] [2Fe-2S] iron-sulfur cluster biosynthesis
S-sulfanyl-[cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex → [cysteine desulfurase]-(S-sulfanyl)2-[disordered-form scaffold protein] complex 2.8.1.- [2Fe-2S] iron-sulfur cluster biosynthesis
S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex → [cysteine desulfurase]-S-sulfanyl-[disordered-form scaffold protein] complex 2.8.1.- [2Fe-2S] iron-sulfur cluster biosynthesis
[S-sulfanyl-L-cysteine desulfurase]2 + [disordered-form [Fe-S] cluster scaffold protein] → S-sulfanyl-[cysteine desulfurase]-[disordered-form scaffold protein] complex [none] [2Fe-2S] iron-sulfur cluster biosynthesis
L-threonine → (2Z)-2-aminobut-2-enoate + H2O + H+ [none] L-isoleucine biosynthesis I (from threonine)
a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA ← a (2E)-2-enoyl-CoA + H2O 4.2.1.17 fatty acid beta-oxidation I
a (3Z)-3-enoyl-CoA → a (2E)-2-enoyl-CoA 5.3.3.8 fatty acid beta-oxidation I
a 2,3,4-saturated (3R)-3-hydroxyacyl-CoA ↔ a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA 5.1.2.3 fatty acid beta-oxidation I
a 2,3,4-saturated fatty acyl CoA + acetyl-CoA ← a 2,3,4-saturated 3-oxoacyl-CoA + coenzyme A 2.3.1.16 fatty acid beta-oxidation I
a 2,3,4-saturated (3S)-3-hydroxyacyl-CoA + NAD+ → a 2,3,4-saturated 3-oxoacyl-CoA + NADH + H+ 1.1.1.35 fatty acid beta-oxidation I
selenodiglutathione + NADPH + H+ → glutathioselenol + glutathione + NADP+ 1.8.1.- selenate reduction
hydrogen selenide + glutathione + NADP+ ← glutathioselenol + NADPH + H+ 1.8.1.- selenate reduction
selenite + AMP + glutathione disulfide + 3 H+ ← adenosine 5'-phosphoselenate + 2 glutathione 1.8.4.9 selenate reduction
2'-deoxyadenosine + H+ + H2O → ammonium + 2'-deoxyinosine 3.5.4.4 purine deoxyribonucleosides degradation I
2'-deoxycytidine + a nucleoside triphosphate → dCMP + a nucleoside diphosphate + H+ 2.7.1.74 pyrimidine deoxyribonucleosides salvage
α-D-ribose-1-phosphate → D-ribose 5-phosphate 5.4.2.7 purine ribonucleosides degradation
adenosine + H2O + H+ → inosine + ammonium 3.5.4.4 purine ribonucleosides degradation
2-deoxy-α-D-ribose 1-phosphate → 2-deoxy-D-ribose 5-phosphate 5.4.2.7 2'-deoxy-alpha-D-ribose 1-phosphate degradation
a queuosine in tRNA + oxidized electron carrier + H2O ← an epoxyqueuosine34 in tRNA + reduced two electron carrier 1.17.99.6 queuosine biosynthesis
7,8-dihydroneopterin 3'-triphosphate + H2O → 7,8-dihydroneopterin 3'-phosphate + diphosphate + H+ 3.6.1.67 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
7,8-dihydroneopterin 3'-phosphate + H2O → 7,8-dihydroneopterin + phosphate 3.6.1.- 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I
an N10-formyltetrahydrofolate + N1-(5-phospho-β-D-ribosyl)glycinamide → a tetrahydrofolate + N2-formyl-N1-(5-phospho-β-D-ribosyl)glycinamide + H+ 2.1.2.2 5-aminoimidazole ribonucleotide biosynthesis I
pppGpp + H2O → ppGpp + phosphate + H+ 3.6.1.40 ppGpp biosynthesis
stearoyl-[acp] + NAD+ ← (2E)-octadec-2-enoyl-[acp] + NADH + H+ 1.3.1.9 stearate biosynthesis II (bacteria and plants)
[ThiS sulfur-carrier protein] + ATP + H+ → carboxy-adenylated-[ThiS sulfur-carrier protein] + diphosphate 2.7.7.73 thiazole biosynthesis I (facultative anaerobic bacteria)
[ThiI sulfur-carrier protein]-S-sulfanyl-L-cysteine + carboxy-adenylated-[ThiS sulfur-carrier protein] + 2 reduced ferredoxin [iron-sulfur] cluster → thiocarboxy-[ThiS-Protein] + [ThiI sulfur-carrier protein]-L-cysteine + AMP + 2 oxidized ferredoxin [iron-sulfur] cluster 2.8.1.- thiazole biosynthesis I (facultative anaerobic bacteria)
palmitoyl-[acp] + NAD+ ← (2E)-hexadec-2-enoyl-[acp] + NADH + H+ 1.3.1.9 palmitate biosynthesis II (bacteria and plants)
myristoyl-[acp] + NAD+ ← (2E)-tetradec-2-enoyl-[acp] + NADH + H+ 1.3.1.9 palmitate biosynthesis II (bacteria and plants)
dodecanoyl-[acp] + NAD+ ← (2E)-dodec-2-enoyl-[acp] + NADH + H+ 1.3.1.9 palmitate biosynthesis II (bacteria and plants)
decanoyl-[acp] + NAD+ ← (2E)-dec-2-enoyl-[acp] + NADH + H+ 1.3.1.9 palmitate biosynthesis II (bacteria and plants)
octanoyl-[acp] + NAD+ ← (2E)-oct-2-enoyl-[acp] + NADH + H+ 1.3.1.9 palmitate biosynthesis II (bacteria and plants)
hexanoyl-[acp] + NAD+ ← (2E)-hex-2-enoyl-[acp] + NADH + H+ 1.3.1.9 palmitate biosynthesis II (bacteria and plants)
butanoyl-[acp] + NAD+ ← (2E)-but-2-enoyl-[acp] + NADH + H+ 1.3.1.9 palmitate biosynthesis II (bacteria and plants)
2-methylbutanoyl-CoA + oxidized electron-transfer flavoprotein + H+ → (E)-2-methylcrotonoyl-CoA + reduced electron-transfer flavoprotein 1.3.8.5 L-isoleucine degradation I
2-methylacetoacetyl-CoA + coenzyme A ↔ propanoyl-CoA + acetyl-CoA 2.3.1.9 L-isoleucine degradation I
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA ← (E)-2-methylcrotonoyl-CoA + H2O 4.2.1.17 L-isoleucine degradation I
(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA + NAD+ → 2-methylacetoacetyl-CoA + NADH + H+ 1.1.1.178 L-isoleucine degradation I
α-D-galacturonosy-(1→4)-α-D-galacturonate → D-galactopyranuronate + 4-deoxy-L-threo-hex-4-enopyranuronate 4.2.2.- pectin degradation I
(1,4-α-D-galacturonosyl)(n+1) + H2O → (1,4-α-D-galacturonosyl)(n) + D-galactopyranuronate 3.2.1.67 pectin degradation II
D-tagaturonate → D-fructuronate 5.1.2.7 pectin degradation II
sarcosine + oxygen + H2O → glycine + formaldehyde + hydrogen peroxide 1.5.3.1 creatinine degradation I
sarcosine + oxidized electron-transfer flavoprotein + H2O + H+ → glycine + formaldehyde + reduced electron-transfer flavoprotein 1.5.8.3 creatinine degradation I
creatine + H2O → urea + sarcosine 3.5.3.3 creatinine degradation I
UDP-N-acetyl-α-D-muramate + L-alanyl-γ-D-glutamyl-meso-diaminopimelate + ATP → UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimelate + ADP + phosphate + H+ 6.3.2.45 anhydromuropeptides recycling I
N-acetyl-α-D-glucosamine 1-phosphate + UTP + H+ → UDP-N-acetyl-α-D-glucosamine + diphosphate 2.7.7.23 UDP-N-acetyl-D-glucosamine biosynthesis I, anhydromuropeptides recycling I
D-glucosamine 1-phosphate + acetyl-CoA → N-acetyl-α-D-glucosamine 1-phosphate + coenzyme A + H+ 2.3.1.157 UDP-N-acetyl-D-glucosamine biosynthesis I, anhydromuropeptides recycling I
GlcNAc-1,6-anhMurNAc-L-Ala-γ-D-Glu-DAP-D-Ala + H2O → N-acetyl-β-D-glucosamine-1,6-anhydro-N-acetyl-β-D-muramate + L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine 3.5.1.28 anhydromuropeptides recycling I
1,6-anhydro-N-acetyl-β-muramate + ATP + H2O → N-acetyl-D-muramate 6-phosphate + ADP + H+ 2.7.1.170 anhydromuropeptides recycling I
dGDP + oxidized thioredoxin + H2O ← GDP + reduced thioredoxin 1.17.4.1 guanosine deoxyribonucleotides de novo biosynthesis I
4-deoxy-2-O-sulfo-β-L-erythro-hex-4-enopyranuronosyl-(1,4)-D-N-sulfoglucosamine 6-O-sulfate + H2O → 4-deoxy-β-L-erythro-hex-4-enopyranuronosyl-(1,4)-D-N-sulfoglucosamine 6-O-sulfate + sulfate + H+ 3.1.6.13 heparin degradation
N,6-O-disulfo-D-glucosamine + H2O → N-sulfo-D-glucosamine + sulfate + H+ 3.1.6.11 heparin degradation
N-sulfo-D-glucosamine + H2O → D-glucosamine + sulfate 3.10.1.1 heparin degradation
L-ribulose + ATP → L-ribulose 5-phosphate + ADP + H+ 2.7.1.16 L-arabinose degradation I
a 5-methyltetrahydrofolate + 2 oxidized ferredoxin [iron-sulfur] cluster ← a 5,10-methylenetetrahydrofolate + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ 1.5.7.1 folate transformations I
a tetrahydrofolate + trimethyl sulfonium ← dimethyl sulfide + a 5-methyltetrahydrofolate + H+ 2.1.1.19 folate transformations I
an (S-diacyl-sn-glyceryl)-L-cysteinyl-[apolipoprotein] + a phosphoglyceride → an N-acyl-(S-diacyl-sn-glyceryl)-L-cysteinyl-[lipoprotein] + a 1-lysophospholipid + H+ 2.3.1.ck lipoprotein posttranslational modification
2,3,4-saturated fatty acyl-[acp] + NAD+ ← trans-2-enoyl-[acyl-carrier protein] + NADH + H+ 1.3.1.9 fatty acid elongation -- saturated
guanosine + H2O → D-ribofuranose + guanine 3.2.2.1 guanine and guanosine salvage II
(cis)-gondoyl-[acp] + NAD+ ← (2E,11Z)-icosa-2,11-dienoyl-[acp] + NADH + H+ 1.3.1.9 gondoate biosynthesis (anaerobic)
gellan → n unsaturated gellan tetrasaccharide 4.2.2.25 gellan degradation
(2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate → di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate 2.5.1.31 di-trans,poly-cis-undecaprenyl phosphate biosynthesis
glycolaldehyde + NAD+ + H2O → glycolate + NADH + 2 H+ 1.2.1.21 D-arabinose degradation I
D-ribulose 1-phosphate → glycolaldehyde + glycerone phosphate [none] D-arabinose degradation I
D-ribulose + ATP → D-ribulose 1-phosphate + ADP + H+ [none] D-arabinose degradation I
an acyl-CoA + sn-glycerol 3-phosphate → a 2-lysophosphatidate + coenzyme A 2.3.1.15 CDP-diacylglycerol biosynthesis I
L-homoserine + ATP → O-phospho-L-homoserine + ADP + H+ 2.7.1.39 L-threonine biosynthesis
acetaldehyde + coenzyme A + NAD+ → acetyl-CoA + NADH + H+ 1.2.1.10 2'-deoxy-alpha-D-ribose 1-phosphate degradation, 2-aminoethylphosphonate degradation I
glycine + a tetrahydrofolate + NAD+ → a 5,10-methylenetetrahydrofolate + ammonium + CO2 + NADH [none] N10-formyl-tetrahydrofolate biosynthesis, folate transformations I
L-glutamate + acetyl-CoA → N-acetyl-L-glutamate + coenzyme A + H+ 2.3.1.1 L-ornithine biosynthesis I
(7,8-dihydropterin-6-yl)methyl diphosphate + 4-aminobenzoate → 7,8-dihydropteroate + diphosphate 2.5.1.15 tetrahydrofolate biosynthesis
UDP-α-D-glucose + α-D-galactose 1-phosphate → UDP-α-D-galactose + α-D-glucopyranose 1-phosphate 2.7.7.12 D-galactose degradation I (Leloir pathway)
demethylated methyl acceptor + S-adenosyl-L-methionine ↔ S-adenosyl-L-homocysteine + methylated methyl acceptor + H+ 2.1.1.- S-adenosyl-L-methionine cycle I, S-adenosyl-L-methionine cycle II, L-methionine degradation I (to L-homocysteine)
S-ribosyl-L-homocysteine → L-homocysteine + autoinducer 2 4.4.1.21 S-adenosyl-L-methionine cycle I
xanthine + NAD+ + H2O → urate + NADH + H+ 1.17.1.4 guanosine nucleotides degradation III, inosine 5'-phosphate degradation
guanine + H+ + H2O → xanthine + ammonium 3.5.4.3 guanosine nucleotides degradation III
nicotinamide + H2O → ammonium + nicotinate 3.5.1.19 NAD salvage pathway I
β-nicotinamide D-ribonucleotide + H2O → D-ribofuranose 5-phosphate + nicotinamide + H+ 3.2.2.14 NAD salvage pathway I
dADP + oxidized thioredoxin + H2O ← ADP + reduced thioredoxin 1.17.4.1 adenosine deoxyribonucleotides de novo biosynthesis
D-erythrose 4-phosphate + NAD+ + H2O → 4-phospho-D-erythronate + NADH + 2 H+ 1.2.1.72 pyridoxal 5'-phosphate biosynthesis I
(R)-pantoate + NADP+ ← 2-dehydropantoate + NADPH + H+ 1.1.1.169 phosphopantothenate biosynthesis I
1,4-dihydroxy-2-naphthoyl-CoA + H2O → 2-carboxy-1,4-naphthoquinol + coenzyme A + H+ 3.1.2.28 2-carboxy-1,4-naphthoquinol biosynthesis
2-succinyl-5-enolpyruvoyl-6-hydroxy-3-cyclohexene-1-carboxylate → (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate 4.2.99.20 2-carboxy-1,4-naphthoquinol biosynthesis

Filled Pathway Holes

Key:
Hole-filler The gene whose product is predicted to catalyze the missing reaction.
Hole EC# The EC number of the missing reaction (links to the reaction page).
P(has-function) The probability that the hole-filler catalyzes the missing reaction as determined by the PHFiller.
All functions of hole-filler All current annotations of the hole-filler, including the function of the missing reaction to which it has been assigned.
Pathway(s) requiring this reaction All metabolic pathways in which the pathway hole occurs in the database.

04:45:15 on Tuesday, 7/29/2025 (GMT-8)

39 pathway holes have been filled by the pathway hole filler, in 175 pathways.

Hole-filler Hole EC# P(has-function) All functions of hole-filler Pathway(s) requiring this reaction
RS00880 2.1.2.- 0.924 formate-dependent phosphoribosylglycinamide formyltransferase superpathway of 5-aminoimidazole ribonucleotide biosynthesis, 5-aminoimidazole ribonucleotide biosynthesis II
RS01400 2.7.1.17 0.983 carbohydrate kinase xylose degradation I
tsaD 2.3.1.234 0.998 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD N6-L-threonylcarbamoyladenosine37-modified tRNA biosynthesis
RS02085 3.1.3.104 0.974 HAD family phosphatase flavin biosynthesis I (bacteria and plants)
RS05915 6.3.5.1 0.999 NAD(+) synthase NAD biosynthesis I (from aspartate), NAD salvage pathway I
RS06515 1.1.1.103 0.948 UDP-glucose 4-epimerase L-threonine degradation II
RS06555 3.6.1.31 1.000 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE L-histidine biosynthesis
RS07320 1.1.1.37 0.997 malate dehydrogenase gluconeogenesis I
RS07605 2.3.1.41 0.996 beta-ketoacyl-[acyl-carrier-protein] synthase family protein stearate biosynthesis II (bacteria and plants)
RS09010 1.1.1.38/1.1.1.39 0.940 NADP-dependent malic enzyme gluconeogenesis I
zwf 1.1.1.49 1.000 glucose-6-phosphate dehydrogenase pentose phosphate pathway (oxidative branch) I
RS09600 3.1.3.11 0.956 fructose-bisphosphatase class III glycolysis I (from glucose 6-phosphate), gluconeogenesis I
RS13055 2.6.1.1 0.980 pyridoxal phosphate-dependent aminotransferase L-glutamate degradation II
RS13065 2.3.1.31 0.971 homoserine O-succinyltransferase L-homocysteine biosynthesis
RS13530 4.1.1.65 1.000 phosphatidylserine decarboxylase family protein phosphatidylethanolamine biosynthesis I
RS14360 4.2.1.9 0.999 dihydroxy-acid dehydratase L-isoleucine biosynthesis IV, L-isoleucine biosynthesis I (from threonine)
RS14360 4.2.1.9 0.999 dihydroxy-acid dehydratase L-valine biosynthesis
ilvC 1.1.1.383 0.956 ketol-acid reductoisomerase L-isoleucine biosynthesis IV
fabG 1.3.1.10/1.3.1.39/1.3.1.104/2.3.1.85/2.3.1.86 0.928 3-oxoacyl-[acyl-carrier-protein] reductase fatty acid elongation -- saturated
RS16525 4.1.3.27 1.000 anthranilate synthase component I L-tryptophan biosynthesis
RS16750 2.7.1.45/2.7.1.178 0.936 sugar kinase D-fructuronate degradation, D-galacturonate degradation I
RS17645 2.6.1.52 1.000 3-phosphoserine/phosphohydroxythreonine transaminase L-serine biosynthesis
gcvP 2.1.2.10 1.000 glycine dehydrogenase (aminomethyl-transferring) glycine cleavage, GCVMULTI-RXN
RS18785 5.4.2.2 0.960 phospho-sugar mutase D-galactose degradation I (Leloir pathway)
RS19030 1.5.1.15 0.983 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase folate transformations I
RS21025 2.7.6.5 1.000 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase ppGpp biosynthesis
RS21025 3.1.7.2 1.000 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase ppGpp biosynthesis
RS22040 2.3.1.129 1.000 acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase lipid IVA biosynthesis
RS22045 4.2.1.59 0.993 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/3-hydroxyacyl-ACP dehydratase palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)
RS22045 4.2.1.59 0.993 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/3-hydroxyacyl-ACP dehydratase palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)
RS22045 4.2.1.59 0.993 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/3-hydroxyacyl-ACP dehydratase gondoate biosynthesis (anaerobic)
aroE 1.1.1.282 0.989 shikimate 5-dehydrogenase chorismate biosynthesis from 3-dehydroquinate
gap 1.2.1.12 0.960 type I glyceraldehyde-3-phosphate dehydrogenase glycolysis I (from glucose 6-phosphate), glycolysis III (from glucose), gluconeogenesis I
RS22260 6.3.5.2 0.995 glutamine-hydrolyzing GMP synthase guanosine ribonucleotides de novo biosynthesis
RS22685 2.7.1.33 0.991 type III pantothenate kinase phosphopantothenate biosynthesis I
RS22775 4.2.1.93 0.997 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase NADH repair
RS22960 4.3.99.3 0.999 radical SAM protein preQ0 biosynthesis
RS23905 3.2.1.56 0.985 glucuronyl hydrolase heparin degradation

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