MetaCyc Metabolic Pathway Database
MetaCyc is a curated database of experimentally elucidated metabolic pathways from all domains of life. MetaCyc contains 2526 pathways from 2844 different organisms.
MetaCyc contains pathways involved in both primary and secondary metabolism, as well as associated metabolites, reactions, enzymes, and genes. The goal of MetaCyc is to catalog the universe of metabolism by storing a representative sample of each experimentally elucidated pathway.
MetaCyc applications include:
- Online encyclopedia of metabolism
- Predict metabolic pathways in sequenced genomes
- Support metabolic engineering via enzyme database
- Metabolite database aids metabolomics research
It is well known that vitamin D is produced in our skin during exposure to the sun. But did you know it is made from cholesterol?Learn More
Biological processes influence geochemical cycles. The main input of sulfur to the atmosphere is dimethyl sulfide, which is formed by microbial degradation of marine algae biomass.Learn More
Reaction Atom Mappings Indicate Atom Flow
The compounds in MetaCyc reactions are color labeled to make it easy to follow the atom flow. You can cause the atoms to be numbered to more clearly identify corresponding atoms in reactants and products.Learn More
So what killed this guy?Learn More
Twenty people were executed around Salem, MA for using witchcraft to afflict young girls. Were the victims bewitched, or could it be something they ate?Learn More
Have you ever swum in the ocean and started to itch? Care to know why?Learn More
Beer is the world's oldest and most widely consumed alcoholic drink, dating back to 9500 BC. Did the ancient Egyptians know all about bitter acids?Learn More
We all know about the A, B, and O blood types, but did you know that a single glycosyltransferase is responsible for all of this diversity?Learn More
Chitin is the second most common polymer in the world, after cellulose. Our understanding of its degradation was significantly boosted with the discovery of LPMOs. And what are LPMOs?Learn More
When oil companies started adding MTBE to gasoline, it seemed like a good idea. Now it is banned in the US, and it is up to the bacteria to degrade the remaining contamination.Learn More
How to Cite MetaCyc
Please cite MetaCyc as Caspi et al 2014, "The MetaCyc database of metabolic pathways and enzymes and the BioCyc collection of Pathway/Genome Databases," Nucleic Acids Research 42:D459-D471
The development of MetaCyc is funded by grant GM080746 from the NIH National Institute of General Medical Sciences.
- BioCyc site contents, including EcoCyc, MetaCyc, and our extensive database collection
- How to search, browse, and find what you need in the BioCyc collection
- How we represent metabolism, transcription, and all their parts
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