MetaCyc Metabolic Pathway Database
MetaCyc is a curated database of experimentally elucidated metabolic pathways from all domains of life. MetaCyc contains 2859 pathways from 3185 different organisms.
MetaCyc contains pathways involved in both primary and secondary metabolism, as well as associated metabolites, reactions, enzymes, and genes. The goal of MetaCyc is to catalog the universe of metabolism by storing a representative sample of each experimentally elucidated pathway.
MetaCyc applications include:
- Online encyclopedia of metabolism
- Predict metabolic pathways in sequenced genomes
- Support metabolic engineering via enzyme database
- Metabolite database aids metabolomics research
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Accessing MetaCyc Data
MetaCyc data can be accessed in several ways:
- Search for pathways, enzymes, reactions, and metabolites through MetaCyc.org
- Download MetaCyc data files
- Browse a list of all MetaCyc metabolic pathways
- Add MetaCyc to your browser search bar for instant MetaCyc searching
How to Cite MetaCyc
Please cite MetaCyc as Caspi et al 2020, "The MetaCyc database of metabolic pathways and enzymes - a 2019 update", Nucleic Acids Research 48(D1):D445-D453
Funding Sources
The development of MetaCyc is funded by grant GM080746 from the NIH National Institute of General Medical Sciences.
Video Tutorials
The BioCyc webinar series introduces users to the basic and advanced features of the BioCyc website and the Pathway Tools software and covers:
- BioCyc site contents, including EcoCyc, MetaCyc, and our extensive database collection
- How to search, browse, and find what you need in the BioCyc collection
- How we represent metabolism, transcription, and all their parts
A complete list of videos in additional download formats are available on the Video and Podcast page.