MetaCyc thiol:disulfide oxidoreductase DsbA

MetaCyc thiol:disulfide oxidoreductase DsbA Skip to main content

gene

enzyme

Escherichia coli K-12 substr. MG1655

Synonyms	dsf; iarA; ppfA; DsbA_reduced; thiol:disulfide oxidoreductase - DsbA_reduced; protein disulfide oxidoreductase DsbA
Accession IDs	EG11297 (MetaCyc) b3860 ECK3852 P0AEG4 (UniProt)	Length	627 bp / 208 aa
		Map Position	[4,043,418 -> 4,044,044]
		Location	periplasm (sensu Gram-negative Bacteria)
Reactions	[reduced DsbA protein] + [oxidized DsbB protein] → [oxidized DsbA protein] + [reduced DsbB protein] 1.8.5.9: [reduced DsbA protein] + electron-transfer quinone → [oxidized DsbA protein] + electron-transfer quinol 1.8.4.15: [oxidized DsbA protein] + apo-[c-type cytochrome] with reduced L-cysteine residues → [reduced DsbA protein] + apo-[c-type cytochrome] with a disulfide bridge + 14 more 1.8.4.15: [oxidized DsbA protein] + a [protein]-dithiol → [reduced DsbA protein] + a [protein]-disulfide 1.8.5.9: [disulfide-bond carrier protein] with reduced L-cysteine residues + electron-transfer quinone → [disulfide-bond carrier protein] carrying a disulfide bond + electron-transfer quinol 1.8.5.9: [disulfide-bond carrier protein] with reduced L-cysteine residues + electron-transfer quinone → [disulfide-bond carrier protein] carrying a disulfide bond + electron-transfer quinol [disulfide-bond carrier protein] with reduced L-cysteine residues + [oxidized DsbB protein] → [disulfide-bond carrier protein] carrying a disulfide bond + [reduced DsbB protein] 1.17.4.4: phylloquinone + protein with a disulfide bond + H₂O ← vitamin K 2,3-epoxide + protein with reduced L-cysteine residues protein with a disulfide bond + reduced glutaredoxin → protein with reduced L-cysteine residues + oxidized glutaredoxin 1.8.4.2: 2 glutathione + protein with a disulfide bond → glutathione disulfide + protein with reduced L-cysteine residues 1.17.4.4: phylloquinol + protein with a disulfide bond ← phylloquinone + protein with reduced L-cysteine residues [reduced DsbG protein]_[periplasm] + protein with incorrect disulfide bonds_[periplasm] → [oxidized DsbG protein]_[periplasm] + protein with reduced L-cysteine residues_[periplasm] [reduced DsbC protein]_[periplasm] + protein with incorrect disulfide bonds_[periplasm] → [oxidized DsbC protein]_[periplasm] + protein with reduced L-cysteine residues_[periplasm] 1.8.4.15: [disulfide-bond carrier protein] carrying a disulfide bond + protein with reduced L-cysteine residues ↔ [disulfide-bond carrier protein] with reduced L-cysteine residues + protein with a disulfide bond 1.8.98.2: a [1-Cys peroxiredoxin]-(S-hydroxy-S-oxocysteine) + ATP + protein with reduced L-cysteine residues → a [1-Cys peroxiredoxin]-(S-hydroxycysteine) + ADP + protein with a disulfide bond + phosphate + H⁺ 1.8.1.8: protein with reduced L-cysteine residues + NAD(P)⁺ ← protein with a disulfide bond + NAD(P)H + H⁺ [protein disulfide isomerase] carrying a disulfide bond + protein with reduced L-cysteine residues → [protein disulfide isomerase] with reduced L-cysteine residues + protein with a disulfide bond [Show fewer]
Pathways	cytochrome c biogenesis (system I type) glutathione-glutaredoxin redox reactions vitamin K-epoxide cycle periplasmic disulfide bond formation
Evidence	Reaction blocked in mutant [Mavridou12]

Summary
GO Terms (8)
Reactions (17)
Protein Features
References
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Page generated by Pathway Tools version 28.5 (software by SRI International) on Tue Apr 8, 2025, BIOCYC18B.
MetaCyc version 28.5.