MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Megathyrsus maximus: pyruvate phosphate dikinaseInferred from experiment
Zea mays: pyruvate orthophosphate dikinaseInferred from experiment: pdk1

In Pathway: L-glutamine biosynthesis III, C4 photosynthetic carbon assimilation cycle, NADP-ME type, C4 photosynthetic carbon assimilation cycle, NAD-ME type, C4 photosynthetic carbon assimilation cycle, PEPCK type

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: pyruvate, phosphate dikinase

Enzyme Commission Synonyms: pyruvate, orthophosphate dikinase, pyruvate-phosphate dikinase (phosphorylating), pyruvate, phosphate dikinase, pyruvate-inorganic phosphate dikinase, pyruvate-phosphate dikinase, pyruvate-phosphate ligase, pyruvic-phosphate dikinase, pyruvic-phosphate ligase, pyruvate, Pi dikinase, PPDK

Standard Gibbs Free Energy (ΔrG in kcal/mol): -13.72406Inferred by computational analysis [Latendresse13]

Citations: [Hatch68, Reeves68, Reeves71a, Reeves68a]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00206, Rhea:10756

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O23404, UniProt:RELATED-TO:O24612, UniProt:RELATED-TO:O85840, UniProt:RELATED-TO:P22221, UniProt:RELATED-TO:P22983, UniProt:RELATED-TO:P37213, UniProt:RELATED-TO:Q7M0I6, UniProt:RELATED-TO:Q9WYA9, UniProt:RELATED-TO:Q39734, UniProt:RELATED-TO:Q39735, UniProt:RELATED-TO:Q41846, UniProt:RELATED-TO:Q42367, UniProt:RELATED-TO:Q42368, UniProt:RELATED-TO:Q42736, UniProt:RELATED-TO:Q42910


Hatch68: Hatch MD, Slack CR (1968). "A new enzyme for the interconversion of pyruvate and phosphopyruvate and its role in the C4 dicarboxylic acid pathway of photosynthesis." Biochem J 106(1);141-6. PMID: 4305612

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Reeves68: Reeves RE (1968). "A new enzyme with the glycolytic function of pyruvate kinase." J Biol Chem 243(11);3202-4. PMID: 4297474

Reeves68a: Reeves RE, Menzies RA, Hsu DS (1968). "The pyruvate-phosphate dikinase reaction. The fate of phosphate and the equilibrium." J Biol Chem 243(20);5486-91. PMID: 4302788

Reeves71a: Reeves RE (1971). "Pyruvate,phosphate dikinase from Bacteroides symbiosus." Biochem J 125(2);531-9. PMID: 5144757

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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