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MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col: plastidic phosphoglucose isomeraseInferred from experiment: PGI1
Bifidobacterium bifidum: glucose-6-phosphate isomeraseInferred from experiment: pgi
Escherichia coli K-12 substr. MG1655: phosphoglucose isomeraseInferred from experiment: pgi
Giardia intestinalis: glucose-6-phosphate isomeraseInferred from experiment: GL50803_9115
Homo sapiens: glucose-6-phosphate isomerase: GPI
Lactobacillus fermentum: glucose-6-phosphate isomeraseInferred from experiment: fruI
Lactococcus lactis: glucose-6-phosphate isomeraseInferred from experiment: pgi
Mycoplasma pneumoniae M129: glucose 6-phosphate isomeraseInferred from experiment: pgi
Pyrococcus furiosus: phosphoglucose isomeraseInferred from experiment: pgiA
Saccharomyces cerevisiae: glucose-6-phosphate isomeraseInferred from experiment: PGI1
Spinacia oleracea: cytosolic glucose-6-phosphate isomeraseInferred from experiment: GPIS
Thermotoga maritima: glucose-6-phosphate isomeraseInferred from experiment: pgi
Triticum aestivum: phosphohexose isomeraseInferred from experiment

In Pathway: chitin biosynthesis, gluconeogenesis II (Methanobacterium thermoautotrophicum), sucrose biosynthesis III, gluconeogenesis I, starch biosynthesis, glycolysis I (from glucose 6-phosphate), UDP-N-acetyl-D-galactosamine biosynthesis II, 1,3-propanediol biosynthesis (engineered), sucrose biosynthesis I (from photosynthesis), sucrose degradation III (sucrose invertase), UDP-N-acetyl-D-glucosamine biosynthesis I, Bifidobacterium shunt, GDP-mannose biosynthesis, glycolysis V (Pyrococcus), heterolactic fermentation, formaldehyde oxidation I, sorbitol biosynthesis I, sucrose degradation II (sucrose synthase), sucrose biosynthesis II, sucrose degradation IV (sucrose phosphorylase), glycolysis III (from glucose), 1,5-anhydrofructose degradation, gluconeogenesis III

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Enzyme Commission Primary Name: glucose-6-phosphate isomerase

Enzyme Commission Synonyms: phosphohexose isomerase, phosphohexomutase, oxoisomerase, hexosephosphate isomerase, phosphosaccharomutase, phosphoglucoisomerase, phosphohexoisomerase, phosphoglucose isomerase, glucose phosphate isomerase, hexose phosphate isomerase, D-glucose-6-phosphate ketol-isomerase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.3800049Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also catalyses the anomerization of D-glucose 6-phosphate.

Citations: [Tsuboi58, Baich60, Nakagawa65, Noltmann64, Ramasarma56]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R00771

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, Rhea:RELATED-TO:11816, UniProt:RELATED-TO:O25781, UniProt:RELATED-TO:O61113, UniProt:RELATED-TO:O82058, UniProt:RELATED-TO:O82059, UniProt:RELATED-TO:O83488, UniProt:RELATED-TO:O84382, UniProt:RELATED-TO:P06744, UniProt:RELATED-TO:P06745, UniProt:RELATED-TO:P08059, UniProt:RELATED-TO:P0A6T1, UniProt:RELATED-TO:P12341, UniProt:RELATED-TO:P12709, UniProt:RELATED-TO:P13375, UniProt:RELATED-TO:P13376, UniProt:RELATED-TO:P13377, UniProt:RELATED-TO:P18240, UniProt:RELATED-TO:P28718, UniProt:RELATED-TO:P29333, UniProt:RELATED-TO:P34796, UniProt:RELATED-TO:P34797, UniProt:RELATED-TO:P42862, UniProt:RELATED-TO:P42863, UniProt:RELATED-TO:P49105, UniProt:RELATED-TO:P50309, UniProt:RELATED-TO:P52983, UniProt:RELATED-TO:P54240, UniProt:RELATED-TO:P54242, UniProt:RELATED-TO:P78033, UniProt:RELATED-TO:P78917, UniProt:RELATED-TO:P81181, UniProt:RELATED-TO:Q7LZP0, UniProt:RELATED-TO:Q9JSS6, UniProt:RELATED-TO:Q9JTW1, UniProt:RELATED-TO:Q9PMD4, UniProt:RELATED-TO:Q9RMC1, UniProt:RELATED-TO:Q9SB57, UniProt:RELATED-TO:Q9X670, UniProt:RELATED-TO:Q59000, UniProt:RELATED-TO:Q59088

Created 17-Sep-2012 by Kothari A, SRI International


Baich60: Baich A, Wolfe RG, Reithel FJ (1960). "The enzymes of mammary gland. I. Isolation of phosphoglucose isomerase." J Biol Chem 235;3130-3. PMID: 13685918

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nakagawa65: Nakagawa Y, Noltmann EA (1965). "Isolation of crystalline phosphoglucose isomerase from brewers' yeast." J Biol Chem 240;1877-81. PMID: 14299604

Noltmann64: Noltmann EA (1964). "Isolation of crystalline phosphoglucose isomerase from rabbit muscle." J Biol Chem 239;1545-50. PMID: 14189891

Ramasarma56: Ramasarma T, Giri KV (1956). "Phosphoglucose isomerase of green gram (Phaseolus radiatus)." Arch Biochem Biophys 62(1);91-6. PMID: 13314642

Tsuboi58: Tsuboi KK, Estrada J, Hudson PB (1958). "Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties." J Biol Chem 231(1);19-29. PMID: 13538944

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sat Apr 30, 2016, biocyc14.