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discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 5.3.1.9

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 5.3.1.9

Enzymes and Genes:
phosphoglucose isomerase Inferred from experiment : pgi ( Escherichia coli K-12 substr. MG1655 )
glucose-6-phosphate isomerase Inferred from experiment : GL50803_9115 ( Giardia intestinalis )
glucose-6-phosphate isomerase Inferred from experiment : pgi ( Bifidobacterium bifidum )
glucose-6-phosphate isomerase Inferred from experiment : pgi ( Lactococcus lactis )
glucose-6-phosphate isomerase Inferred from experiment : fruI ( Lactobacillus fermentum )
phosphohexose isomerase Inferred from experiment ( Triticum aestivum )
plastidic phosphoglucose isomerase Inferred from experiment : PGI1 ( Arabidopsis thaliana col )
phosphoglucose isomerase Inferred from experiment : pgiA ( Pyrococcus furiosus )
glucose-6-phosphate isomerase Inferred from experiment : PGI1 ( Saccharomyces cerevisiae )
cytosolic glucose-6-phosphate isomerase Inferred from experiment : GPIS ( Spinacia oleracea )
glucose 6-phosphate isomerase Inferred from experiment : pgi ( Mycoplasma pneumoniae M129 )
glucose-6-phosphate isomerase Inferred from experiment : pgi ( Thermotoga maritima )
glucose-6-phosphate isomerase : GPI ( Homo sapiens )

In Pathway: sorbitol biosynthesis I , sucrose degradation IV (sucrose phosphorylase) , heterolactic fermentation , formaldehyde oxidation I , glycolysis V (Pyrococcus) , GDP-mannose biosynthesis , Bifidobacterium shunt , gluconeogenesis II (Methanobacterium thermoautotrophicum) , chitin biosynthesis , gluconeogenesis I , sucrose biosynthesis II , starch biosynthesis , mannitol cycle , UDP-N-acetyl-D-glucosamine biosynthesis I , sucrose degradation III (sucrose invertase) , sucrose biosynthesis I (from photosynthesis) , 1,3-propanediol biosynthesis (engineered) , UDP-N-acetyl-D-galactosamine biosynthesis II , sucrose biosynthesis III , glycolysis III (from glucose) , glycolysis I (from glucose 6-phosphate)

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Direct generic reaction:
D-glucopyranose 6-phosphate ↔ β-D-fructofuranose 6-phosphate (5.3.1.9)

Enzyme Commission Primary Name: glucose-6-phosphate isomerase

Enzyme Commission Synonyms: phosphohexose isomerase, phosphohexomutase, oxoisomerase, hexosephosphate isomerase, phosphosaccharomutase, phosphoglucoisomerase, phosphohexoisomerase, phosphoglucose isomerase, glucose phosphate isomerase, hexose phosphate isomerase, D-glucose-6-phosphate ketol-isomerase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.3800049 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also catalyses the anomerization of D-glucose 6-phosphate.

Citations: [Tsuboi58, Baich60, Nakagawa65, Noltmann64, Ramasarma56]

Gene-Reaction Schematic: ?

Instance reactions of [D-glucopyranose 6-phosphate ↔ β-D-fructofuranose 6-phosphate] (5.3.1.9):
i1: α-D-glucose 6-phosphate ↔ β-D-fructofuranose 6-phosphate (5.3.1.9)

i2: β-D-glucose 6-phosphate ↔ β-D-fructofuranose 6-phosphate (5.3.1.9)

Unification Links: KEGG:R00771

Relationship Links: BRENDA:EC:5.3.1.9 , ENZYME:EC:5.3.1.9 , IUBMB-ExplorEnz:EC:5.3.1.9 , Rhea:RELATED-TO:11816 , UniProt:RELATED-TO:O25781 , UniProt:RELATED-TO:O61113 , UniProt:RELATED-TO:O82058 , UniProt:RELATED-TO:O82059 , UniProt:RELATED-TO:O83488 , UniProt:RELATED-TO:O84382 , UniProt:RELATED-TO:P06744 , UniProt:RELATED-TO:P06745 , UniProt:RELATED-TO:P08059 , UniProt:RELATED-TO:P0A6T1 , UniProt:RELATED-TO:P12341 , UniProt:RELATED-TO:P12709 , UniProt:RELATED-TO:P13375 , UniProt:RELATED-TO:P13376 , UniProt:RELATED-TO:P13377 , UniProt:RELATED-TO:P18240 , UniProt:RELATED-TO:P28718 , UniProt:RELATED-TO:P29333 , UniProt:RELATED-TO:P34796 , UniProt:RELATED-TO:P34797 , UniProt:RELATED-TO:P42862 , UniProt:RELATED-TO:P42863 , UniProt:RELATED-TO:P49105 , UniProt:RELATED-TO:P50309 , UniProt:RELATED-TO:P52983 , UniProt:RELATED-TO:P54240 , UniProt:RELATED-TO:P54242 , UniProt:RELATED-TO:P78033 , UniProt:RELATED-TO:P78917 , UniProt:RELATED-TO:P81181 , UniProt:RELATED-TO:Q7LZP0 , UniProt:RELATED-TO:Q9JSS6 , UniProt:RELATED-TO:Q9JTW1 , UniProt:RELATED-TO:Q9PMD4 , UniProt:RELATED-TO:Q9RMC1 , UniProt:RELATED-TO:Q9SB57 , UniProt:RELATED-TO:Q9X670 , UniProt:RELATED-TO:Q59000 , UniProt:RELATED-TO:Q59088


References

Baich60: Baich A, Wolfe RG, Reithel FJ (1960). "The enzymes of mammary gland. I. Isolation of phosphoglucose isomerase." J Biol Chem 235;3130-3. PMID: 13685918

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nakagawa65: Nakagawa Y, Noltmann EA (1965). "ISOLATION OF CRYSTALLINE PHOSPHOGLUCOSE ISOMERASE FROM BREWERS' YEAST." J Biol Chem 240;1877-81. PMID: 14299604

Noltmann64: Noltmann EA (1964). "ISOLATION OF CRYSTALLINE PHOSPHOGLUCOSE ISOMERASE FROM RABBIT MUSCLE." J Biol Chem 239;1545-50. PMID: 14189891

Ramasarma56: Ramasarma T, Giri KV (1956). "Phosphoglucose isomerase of green gram (Phaseolus radiatus)." Arch Biochem Biophys 62(1);91-6. PMID: 13314642

Tsuboi58: Tsuboi KK, Estrada J, Hudson PB (1958). "Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties." J Biol Chem 231(1);19-29. PMID: 13538944


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Thu Dec 18, 2014, BIOCYC14B.