MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number:

Enzymes and Genes:

Arabidopsis thaliana col : plastidic phosphoglucose isomerase Inferred from experiment : PGI1
Bifidobacterium bifidum : glucose-6-phosphate isomerase Inferred from experiment : pgi
Escherichia coli K-12 substr. MG1655 : phosphoglucose isomerase Inferred from experiment : pgi
Giardia intestinalis : glucose-6-phosphate isomerase Inferred from experiment : GL50803_9115
Homo sapiens : glucose-6-phosphate isomerase : GPI
Lactobacillus fermentum : glucose-6-phosphate isomerase Inferred from experiment : fruI
Lactococcus lactis : glucose-6-phosphate isomerase Inferred from experiment : pgi
Mycoplasma pneumoniae M129 : glucose 6-phosphate isomerase Inferred from experiment : pgi
Pyrococcus furiosus : phosphoglucose isomerase Inferred from experiment : pgiA
Saccharomyces cerevisiae : glucose-6-phosphate isomerase Inferred from experiment : PGI1
Spinacia oleracea : cytosolic glucose-6-phosphate isomerase Inferred from experiment : GPIS
Thermotoga maritima : glucose-6-phosphate isomerase Inferred from experiment : pgi
Triticum aestivum : phosphohexose isomerase Inferred from experiment

In Pathway: sorbitol biosynthesis I , sucrose degradation IV (sucrose phosphorylase) , heterolactic fermentation , formaldehyde oxidation I , glycolysis V (Pyrococcus) , GDP-mannose biosynthesis , Bifidobacterium shunt , gluconeogenesis II (Methanobacterium thermoautotrophicum) , chitin biosynthesis , gluconeogenesis I , sucrose biosynthesis II , UDP-N-acetyl-D-glucosamine biosynthesis I , sucrose degradation III (sucrose invertase) , sucrose biosynthesis I (from photosynthesis) , 1,3-propanediol biosynthesis (engineered) , UDP-N-acetyl-D-galactosamine biosynthesis II , sucrose biosynthesis III , glycolysis III (from glucose) , glycolysis I (from glucose 6-phosphate) , starch biosynthesis

Note that this reaction equation differs from the official Enzyme Commission reaction equation for this EC number, which can be found here .

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

Mass balance status: Balanced.

Direct generic reaction:
D-glucopyranose 6-phosphate ↔ β-D-fructofuranose 6-phosphate (

Enzyme Commission Primary Name: glucose-6-phosphate isomerase

Enzyme Commission Synonyms: phosphohexose isomerase, phosphohexomutase, oxoisomerase, hexosephosphate isomerase, phosphosaccharomutase, phosphoglucoisomerase, phosphohexoisomerase, phosphoglucose isomerase, glucose phosphate isomerase, hexose phosphate isomerase, D-glucose-6-phosphate ketol-isomerase

Standard Gibbs Free Energy (ΔrG in kcal/mol): 1.3800049 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also catalyses the anomerization of D-glucose 6-phosphate.

Citations: [Tsuboi58, Baich60, Nakagawa65, Noltmann64, Ramasarma56]

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Instance reactions of [D-glucopyranose 6-phosphate ↔ β-D-fructofuranose 6-phosphate] (
i1: α-D-glucose 6-phosphate ↔ β-D-fructofuranose 6-phosphate (

i2: β-D-glucose 6-phosphate ↔ β-D-fructofuranose 6-phosphate (

Unification Links: KEGG:R00771

Relationship Links: BRENDA:EC: , ENZYME:EC: , IUBMB-ExplorEnz:EC: , Rhea:RELATED-TO:11816 , UniProt:RELATED-TO:O25781 , UniProt:RELATED-TO:O61113 , UniProt:RELATED-TO:O82058 , UniProt:RELATED-TO:O82059 , UniProt:RELATED-TO:O83488 , UniProt:RELATED-TO:O84382 , UniProt:RELATED-TO:P06744 , UniProt:RELATED-TO:P06745 , UniProt:RELATED-TO:P08059 , UniProt:RELATED-TO:P0A6T1 , UniProt:RELATED-TO:P12341 , UniProt:RELATED-TO:P12709 , UniProt:RELATED-TO:P13375 , UniProt:RELATED-TO:P13376 , UniProt:RELATED-TO:P13377 , UniProt:RELATED-TO:P18240 , UniProt:RELATED-TO:P28718 , UniProt:RELATED-TO:P29333 , UniProt:RELATED-TO:P34796 , UniProt:RELATED-TO:P34797 , UniProt:RELATED-TO:P42862 , UniProt:RELATED-TO:P42863 , UniProt:RELATED-TO:P49105 , UniProt:RELATED-TO:P50309 , UniProt:RELATED-TO:P52983 , UniProt:RELATED-TO:P54240 , UniProt:RELATED-TO:P54242 , UniProt:RELATED-TO:P78033 , UniProt:RELATED-TO:P78917 , UniProt:RELATED-TO:P81181 , UniProt:RELATED-TO:Q7LZP0 , UniProt:RELATED-TO:Q9JSS6 , UniProt:RELATED-TO:Q9JTW1 , UniProt:RELATED-TO:Q9PMD4 , UniProt:RELATED-TO:Q9RMC1 , UniProt:RELATED-TO:Q9SB57 , UniProt:RELATED-TO:Q9X670 , UniProt:RELATED-TO:Q59000 , UniProt:RELATED-TO:Q59088


Baich60: Baich A, Wolfe RG, Reithel FJ (1960). "The enzymes of mammary gland. I. Isolation of phosphoglucose isomerase." J Biol Chem 235;3130-3. PMID: 13685918

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nakagawa65: Nakagawa Y, Noltmann EA (1965). "Isolation of crystalline phosphoglucose isomerase from brewers' yeast." J Biol Chem 240;1877-81. PMID: 14299604

Noltmann64: Noltmann EA (1964). "Isolation of crystalline phosphoglucose isomerase from rabbit muscle." J Biol Chem 239;1545-50. PMID: 14189891

Ramasarma56: Ramasarma T, Giri KV (1956). "Phosphoglucose isomerase of green gram (Phaseolus radiatus)." Arch Biochem Biophys 62(1);91-6. PMID: 13314642

Tsuboi58: Tsuboi KK, Estrada J, Hudson PB (1958). "Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties." J Biol Chem 231(1);19-29. PMID: 13538944

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Mon Oct 5, 2015, biocyc13.