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MetaCyc Reaction: 2.7.4.9/2.7.4.12/2.7.4.13

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateSmall-Molecule Reactions

EC Number: 2.7.4.9, 2.7.4.12, 2.7.4.13

Enzymes and Genes:

Arabidopsis thaliana col: thymidylate kinaseInferred from experiment: TMPK
Escherichia coli K-12 substr. MG1655: dTMP kinaseInferred from experiment: tmk
Homo sapiens: thymidylate kinaseInferred from experiment: DTYMK
Mycobacterium tuberculosis H37Rv: thymidylate kinaseInferred from experiment: tmk
Saccharomyces cerevisiae: thymidylate kinaseInferred from experiment: CDC8

In Pathway: pyrimidine deoxyribonucleotides de novo biosynthesis II, superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli), pyrimidine deoxyribonucleotides de novo biosynthesis III, pyrimidine deoxyribonucleotides de novo biosynthesis I, pyrimidine deoxyribonucleotides de novo biosynthesis IV, pyrimidine deoxyribonucleotide phosphorylation, pyrimidine deoxyribonucleotides biosynthesis from CTP

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name for 2.7.4.9: dTMP kinase

Enzyme Commission Synonyms for 2.7.4.9: thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, deoxythymidine 5'-monophosphate kinase, TMPK, thymidine 5'-monophosphate kinase

Enzyme Commission Primary Name for 2.7.4.12: T2-induced deoxynucleotide kinase

Enzyme Commission Primary Name for 2.7.4.13: (deoxy)nucleoside-phosphate kinase

Enzyme Commission Synonyms for 2.7.4.13: deoxynucleoside monophosphate kinase, deoxyribonucleoside monophosphokinase, deoxynucleoside-5'-monophosphate kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.78582764Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary for 2.7.4.12:
dGMP and dGDP can be used in place of dTMP and dTDP, respectively.

dTMP and dAMP can act as acceptors; dATP can act as donor.

Enzyme Commission Summary for 2.7.4.13:
dATP can substitute for ATP.

Citations: [Hurwitz59, Kielley70, Nelson69, Bello63, BESSMAN65]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R02094, KEGG:R02094, Rhea:13517

Relationship Links: BRENDA:EC:2.7.4.9, BRENDA:EC:2.7.4.12, BRENDA:EC:2.7.4.13, ENZYME:EC:2.7.4.9, ENZYME:EC:2.7.4.12, ENZYME:EC:2.7.4.13, IUBMB-ExplorEnz:EC:2.7.4.9, IUBMB-ExplorEnz:EC:2.7.4.12, IUBMB-ExplorEnz:EC:2.7.4.13, UniProt:RELATED-TO:O81650, UniProt:RELATED-TO:P00572, UniProt:RELATED-TO:P0A720, UniProt:RELATED-TO:P23919, UniProt:RELATED-TO:P33803, UniProt:RELATED-TO:P36590, UniProt:RELATED-TO:P42490, UniProt:RELATED-TO:P68693, UniProt:RELATED-TO:Q8X8H7, UniProt:RELATED-TO:Q9JVE7, UniProt:RELATED-TO:Q9PPF3, UniProt:RELATED-TO:Q9RA29, UniProt:RELATED-TO:Q80HT9, UniProt:RELATED-TO:Q57741


References

Bello63: Bello LJ, Bessman MJ (1963). "The enzymology of virus-infected bacteria. IV. Purification and properties of the deoxynucleotide kinase induced by bacteriophage T2." J Biol Chem 238;1777-87. PMID: 13967158

BESSMAN65: BESSMAN MJ, HERRIOTT ST, ORR MJ (1965). "THE ENZYMOLOGY OF VIRUS-INFECTED BACTERIA. VI. PURIFICATION AND PROPERTIES OF THE DEOXYNUCLEOTIDE KINASE INDUCED BY BACTERIOPHAGE T5." J Biol Chem 240;439-45. PMID: 14253449

Hurwitz59: Hurwitz J (1959). "The enzymatic incorporation of ribonucleotides into polydeoxynucletide material." J Biol Chem 234;2351-8. PMID: 14405566

Kielley70: Kielley RK (1970). "Purification and properties of thymidine monophosphate kinase from mouse hepatoma." J Biol Chem 245(16);4204-12. PMID: 4323166

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nelson69: Nelson DJ, Carter CE (1969). "Purification and characterization of Thymidine 5-monophosphate kinase from Escherichia coli B." J Biol Chem 1969;244(19);5254-62. PMID: 4899016


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by Pathway Tools version 19.5 (software by SRI International) on Sun May 1, 2016, biocyc14.