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discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Reaction: 2.7.4.9/2.7.4.12/2.7.4.13

Superclasses: Reactions Classified By Conversion Type Simple Reactions Chemical Reactions
Reactions Classified By Substrate Small-Molecule Reactions

EC Number: 2.7.4.9 , 2.7.4.12 , 2.7.4.13

Enzymes and Genes:
dTMP kinase Inferred from experiment : tmk ( Escherichia coli K-12 substr. MG1655 )
thymidylate kinase Inferred from experiment : CDC8 ( Saccharomyces cerevisiae )
thymidylate kinase Inferred from experiment : DTYMK ( Homo sapiens )
thymidylate kinase Inferred from experiment : TMPK ( Arabidopsis thaliana col )
thymidylate kinase Inferred from experiment : tmk ( Mycobacterium tuberculosis H37Rv )

In Pathway: pyrimidine deoxyribonucleotides de novo biosynthesis II , superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) , pyrimidine deoxyribonucleotides de novo biosynthesis III , pyrimidine deoxyribonucleotides de novo biosynthesis I , pyrimidine deoxyribonucleotides de novo biosynthesis IV , pyrimidine deoxyribonucleotide phosphorylation , pyrimidine deoxyribonucleotides biosynthesis from CTP

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name for 2.7.4.9: dTMP kinase

Enzyme Commission Synonyms for 2.7.4.9: thymidine monophosphate kinase, thymidylate kinase, thymidylate monophosphate kinase, thymidylic acid kinase, thymidylic kinase, deoxythymidine 5'-monophosphate kinase, TMPK, thymidine 5'-monophosphate kinase

Enzyme Commission Primary Name for 2.7.4.12: T2-induced deoxynucleotide kinase

Enzyme Commission Primary Name for 2.7.4.13: (deoxy)nucleoside-phosphate kinase

Enzyme Commission Synonyms for 2.7.4.13: deoxynucleoside monophosphate kinase, deoxyribonucleoside monophosphokinase, deoxynucleoside-5'-monophosphate kinase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -0.78582764 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary for 2.7.4.12:
dGMP and dGDP can be used in place of dTMP and dTDP, respectively.

dTMP and dAMP can act as acceptors; dATP can act as donor.

Enzyme Commission Summary for 2.7.4.13:
dATP can substitute for ATP.

Citations: [Hurwitz59, Kielley70, Nelson69, Bello63, BESSMAN65]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R02094 , KEGG:R02094 , Rhea:13517

Relationship Links: BRENDA:EC:2.7.4.9 , BRENDA:EC:2.7.4.12 , BRENDA:EC:2.7.4.13 , ENZYME:EC:2.7.4.9 , ENZYME:EC:2.7.4.12 , ENZYME:EC:2.7.4.13 , IUBMB-ExplorEnz:EC:2.7.4.9 , IUBMB-ExplorEnz:EC:2.7.4.12 , IUBMB-ExplorEnz:EC:2.7.4.13 , UniProt:RELATED-TO:O81650 , UniProt:RELATED-TO:P00572 , UniProt:RELATED-TO:P0A720 , UniProt:RELATED-TO:P23919 , UniProt:RELATED-TO:P33803 , UniProt:RELATED-TO:P36590 , UniProt:RELATED-TO:P42490 , UniProt:RELATED-TO:P68693 , UniProt:RELATED-TO:Q8X8H7 , UniProt:RELATED-TO:Q9JVE7 , UniProt:RELATED-TO:Q9PPF3 , UniProt:RELATED-TO:Q9RA29 , UniProt:RELATED-TO:Q80HT9 , UniProt:RELATED-TO:Q57741


References

Bello63: Bello LJ, Bessman MJ (1963). "The enzymology of virus-infected bacteria. IV. Purification and properties of the deoxynucleotide kinase induced by bacteriophage T2." J Biol Chem 238;1777-87. PMID: 13967158

BESSMAN65: BESSMAN MJ, HERRIOTT ST, ORR MJ (1965). "THE ENZYMOLOGY OF VIRUS-INFECTED BACTERIA. VI. PURIFICATION AND PROPERTIES OF THE DEOXYNUCLEOTIDE KINASE INDUCED BY BACTERIOPHAGE T5." J Biol Chem 240;439-45. PMID: 14253449

Hurwitz59: Hurwitz J (1959). "The enzymatic incorporation of ribonucleotides into polydeoxynucletide material." J Biol Chem 234;2351-8. PMID: 14405566

Kielley70: Kielley RK (1970). "Purification and properties of thymidine monophosphate kinase from mouse hepatoma." J Biol Chem 245(16);4204-12. PMID: 4323166

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

Nelson69: Nelson DJ, Carter CE (1969). "Purification and characterization of Thymidine 5-monophosphate kinase from Escherichia coli B." J Biol Chem 1969;244(19);5254-62. PMID: 4899016


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Wed Nov 26, 2014, BIOCYC14A.