MetaCyc Reaction: 4.3.2.2

Superclasses: Reactions-Classified-By-Conversion-Type Simple-Reactions Chemical-Reactions
Reactions-Classified-By-Substrate Small-Molecule-Reactions

EC Number: 4.3.2.2

Enzymes and Genes:
adenylosuccinate lyase Inferred from experiment : purB ( Escherichia coli K-12 substr. MG1655 )
adenylosuccinate lyase Inferred from experiment : ADSL ( Homo sapiens )
adenylosuccinate lyase Inferred from experiment : ade13 ( Saccharomyces cerevisiae )

In Pathway: adenosine ribonucleotides de novo biosynthesis

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

Mass balance status: Balanced.

Enzyme Commission Primary Name: adenylosuccinate lyase

Enzyme Commission Synonyms: adenylosuccinase, succino AMP-lyase, 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase, 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

Standard Gibbs Free Energy (ΔrG in kcal/mol): 55.0455 Inferred by computational analysis [Latendresse13]

Enzyme Commission Summary:
Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole.

Citations: [CARTER56]

Gene-Reaction Schematic: ?

Unification Links: KEGG:R01083 , Rhea:16853

Relationship Links: BRENDA:EC:4.3.2.2 , ENZYME:EC:4.3.2.2 , IUBMB-ExplorEnz:EC:4.3.2.2 , UniProt:RELATED-TO:O65180 , UniProt:RELATED-TO:P0AB89 , UniProt:RELATED-TO:P12047 , UniProt:RELATED-TO:P21265 , UniProt:RELATED-TO:Q9CF40 , UniProt:RELATED-TO:Q9JSP3 , UniProt:RELATED-TO:Q9PJ88 , UniProt:RELATED-TO:Q58339


References

CARTER56: CARTER CE, COHEN LH (1956). "The preparation and properties of adenylosuccinase and adenylosuccinic acid." J Biol Chem 222(1);17-30. PMID: 13366975

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 38:D473-D479 2010
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