MetaCyc Reaction:

Superclasses: Reactions Classified By Conversion TypeSimple ReactionsChemical Reactions
Reactions Classified By SubstrateMacromolecule ReactionsPolynucleotide-ReactionsRNA-ReactionstRNA-ReactionstRNA-Charging-Reactions

EC Number:

Enzymes and Genes:

Escherichia coli K-12 substr. MG1655: alanyl-tRNA synthetase and DNA-binding transcriptional repressorInferred from experiment: alaS

In Pathway: tRNA charging

The direction shown, i.e. which substrates are on the left and right sides, is in accordance with the direction in which it was curated.

Most BioCyc compounds have been protonated to a reference pH value of 7.3. Please see the PGDB Concepts Guide for more information.

Mass balance status: Balanced.

Enzyme Commission Primary Name: alanine—tRNA ligase

Enzyme Commission Synonyms: alanyl-tRNA synthetase, alanyl-transfer ribonucleate synthetase, alanyl-transfer RNA synthetase, alanyl-transfer ribonucleic acid synthetase, alanine-transfer RNA ligase, alanine transfer RNA synthetase, alanine tRNA synthetase, alanine translase, alanyl-transfer ribonucleate synthase, AlaRS, Ala-tRNA synthetase

Standard Gibbs Free Energy (ΔrG in kcal/mol): -71.29132Inferred by computational analysis [Latendresse13]

Citations: [HOLLEY59, WEBSTER61]

Gene-Reaction Schematic

Gene-Reaction Schematic

Unification Links: KEGG:R03038, Rhea:12540

Relationship Links: BRENDA:EC:, ENZYME:EC:, IUBMB-ExplorEnz:EC:, UniProt:RELATED-TO:O27718, UniProt:RELATED-TO:O34526, UniProt:RELATED-TO:O50189, UniProt:RELATED-TO:O51238, UniProt:RELATED-TO:O58035, UniProt:RELATED-TO:O67323, UniProt:RELATED-TO:O83980, UniProt:RELATED-TO:P00957, UniProt:RELATED-TO:P21894, UniProt:RELATED-TO:P24075, UniProt:RELATED-TO:P27866, UniProt:RELATED-TO:P35029, UniProt:RELATED-TO:P40825, UniProt:RELATED-TO:P43815, UniProt:RELATED-TO:P47534, UniProt:RELATED-TO:P49588, UniProt:RELATED-TO:P50475, UniProt:RELATED-TO:P56452, UniProt:RELATED-TO:P75368, UniProt:RELATED-TO:Q9CEW0, UniProt:RELATED-TO:Q9JTG4, UniProt:RELATED-TO:Q9PI05, UniProt:RELATED-TO:Q9X1B6, UniProt:RELATED-TO:Q9Z714, UniProt:RELATED-TO:Q9ZCA4, UniProt:RELATED-TO:Q9ZJY5, UniProt:RELATED-TO:Q48976, UniProt:RELATED-TO:Q57984


HOLLEY59: HOLLEY RW, GOLDSTEIN J (1959). "An alanine-dependent, ribonuclease-inhibited conversion of adenosine 5'-phosphate to adenosine triphosphate. II. Reconstruction of the system from purified components." J Biol Chem 234(7);1765-8. PMID: 13672960

Latendresse13: Latendresse M. (2013). "Computing Gibbs Free Energy of Compounds and Reactions in MetaCyc."

WEBSTER61: WEBSTER GC (1961). "Isolation of an alanine-activating enzyme from pig liver." Biochim Biophys Acta 49;141-52. PMID: 13783653

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.5 on Fri Nov 27, 2015, BIOCYC13A.