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Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
Metabolic Modeling Tutorial
discounted EARLY registration ends Dec 31, 2014
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MetaCyc Enzyme: 4-hydroxyphenylpyruvate dioxygenase

Gene: slr0090 Accession Number: G-10608 (MetaCyc)

Species: Synechocystis sp. PCC 6803

Summary:
The slr0090 gene of Synechocystis sp. PCC 6803 was identified based on a high homology to plant genes encoding 4-hydroxyphenylpyruvate dioxygenases. Disruption of the gene resulted in impairment of tocopherol biosynthesis, as expected [Dahnhardt02]. However, the disruption had no effect on the biosynthesis of plastoquinone-9, carotenoids and chlorophyll. This finding suggests that cyanobacteria may possess a different pathway for the biosynthesis of plastoquinone that does not involve 4-hydroxyphenylpyruvate dioxygenase.

Molecular Weight of Polypeptide: 38.59 kD (from nucleotide sequence)

Unification Links: Entrez-gene:952328 , Protein Model Portal:Q55810 , String:1148.slr0090 , UniProt:Q55810

Relationship Links: InterPro:IN-FAMILY:IPR004360 , InterPro:IN-FAMILY:IPR005956 , Panther:IN-FAMILY:PTHR11959 , Pfam:IN-FAMILY:PF00903

Gene-Reaction Schematic: ?

Credits:
Created 23-Apr-2008 by Caspi R , SRI International


Enzymatic reaction of: 4-hydroxyphenylpyruvate dioxygenase

EC Number: 1.13.11.27

4-hydroxyphenylpyruvate + oxygen <=> CO2 + homogentisate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the Enzyme Commission system.

The reaction is physiologically favored in the direction shown.

In Pathways: superpathway of plastoquinol biosynthesis , vitamin E biosynthesis (tocopherols)


References

Dahnhardt02: Dahnhardt D, Falk J, Appel J, van der Kooij TA, Schulz-Friedrich R, Krupinska K (2002). "The hydroxyphenylpyruvate dioxygenase from Synechocystis sp. PCC 6803 is not required for plastoquinone biosynthesis." FEBS Lett 523(1-3);177-81. PMID: 12123828


Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Nov 23, 2014, BIOCYC14A.