MetaCyc Enzyme: 4-hydroxyphenylpyruvate dioxygenase

Gene: slr0090 Accession Number: G-10608 (MetaCyc)

Species: Synechocystis sp. PCC 6803

The slr0090 gene of Synechocystis sp. PCC 6803 was identified based on a high homology to plant genes encoding 4-hydroxyphenylpyruvate dioxygenases. Disruption of the gene resulted in impairment of tocopherol biosynthesis, as expected [Dahnhardt02]. However, the disruption had no effect on the biosynthesis of plastoquinone-9, carotenoids and chlorophyll. This finding suggests that cyanobacteria may possess a different pathway for the biosynthesis of plastoquinone that does not involve 4-hydroxyphenylpyruvate dioxygenase.

Molecular Weight of Polypeptide: 38.59 kD (from nucleotide sequence)

Unification Links: Entrez-gene:952328 , Protein Model Portal:Q55810 , String:1148.slr0090 , UniProt:Q55810

Relationship Links: InterPro:IN-FAMILY:IPR004360 , InterPro:IN-FAMILY:IPR005956 , InterPro:IN-FAMILY:IPR029068 , Panther:IN-FAMILY:PTHR11959 , Pfam:IN-FAMILY:PF00903

Gene-Reaction Schematic: ?

Gene-Reaction Schematic

Created 23-Apr-2008 by Caspi R , SRI International

Enzymatic reaction of: 4-hydroxyphenylpyruvate dioxygenase

EC Number:

4-hydroxyphenylpyruvate + oxygen <=> CO2 + homogentisate

The reaction direction shown, that is, A + B ↔ C + D versus C + D ↔ A + B, is in accordance with the direction in which it was curated.

The reaction is physiologically favored in the direction shown.

In Pathways: superpathway of plastoquinol biosynthesis , vitamin E biosynthesis (tocopherols)


Dahnhardt02: Dahnhardt D, Falk J, Appel J, van der Kooij TA, Schulz-Friedrich R, Krupinska K (2002). "The hydroxyphenylpyruvate dioxygenase from Synechocystis sp. PCC 6803 is not required for plastoquinone biosynthesis." FEBS Lett 523(1-3);177-81. PMID: 12123828

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 19.0 on Wed Oct 7, 2015, BIOCYC14A.