MetaCyc EC -- carboxylesterase

Parent Class: EC-Numbers 3 -- Hydrolases 3.1 -- Acting on ester bonds 3.1.1 -- Carboxylic ester hydrolases

Synonyms: ali-esterase, B-esterase, monobutyrase, procaine esterase, vitamin A esterase, butyryl esterase, carboxyesterase, carboxylate esterase, carboxylic esterase, methylbutyrate esterase, triacetin esterase, carboxyl ester hydrolase, butyrate esterase, methylbutyrase, α-carboxylesterase, propionyl esterase, nonspecific carboxylesterase, esterase D, esterase B, esterase A, serine esterase, carboxylic acid esterase, cocaine esterase

Systematic Name: carboxylic-ester hydrolase

Unification Links: BRENDA: , ENZYME: , IUBMB-ExplorEnz:

a carboxylic ester + H2O → an alcohol + a carboxylate + H+

Unofficial Reactions:
1-O-methylsalicylate + H2O → salicylate + methanol + H+ ,
all-trans-retinyl palmitate + H2O → all-trans-retinol + palmitate + H+ ,
salicyl-6-hydroxy-2-cyclohexene-on-oyl + H2O → 6-hydroxy-2-cyclohexen-one-carboxylate + salicyl alcohol + H+ ,
a methyl jasmonate + H2O → a jasmonic acid + methanol + H+ ,
an all-trans-retinyl ester + H2O → all-trans-retinol + a long-chain fatty acid + H+ ,
all-trans-retinyl palmitate + H2O → a retinol + palmitate + H+ ,
methyl (indol-3-yl)acetate + H2O → indole-3-acetate + methanol + H+

Enzymes and Genes:
pimeloyl-[acp] methyl ester esterase : bioH ( Escherichia coli K-12 substr. MG1655 )
carboxylesterase 3 : CES3 ( Homo sapiens )
liver carboxylesterase 1 : CES1 ( Homo sapiens )

Wide specificity. The enzymes from microsomes also catalyse the reactions of EC (arylesterase), EC (lysophospholipase), EC (acetylesterase), EC (acylglycerol lipase), EC (acylcarnitine hydrolase), EC (palmitoyl-CoA hydrolase), EC (amidase) and EC (aryl-acylamidase). Also hydrolyses vitamin A esters.

Citations: [Augusteyn69, Barker69, Bertram69, BURCH54, Horgan69, Mentlein84, Runnegar69, Malhotra66]


Augusteyn69: Augusteyn RC, de Jersey J, Webb EC, Zerner B (1969). "On the homology of the active-site peptides of liver carboxylesterases." Biochim Biophys Acta 171(1);128-37. PMID: 4884138

Barker69: Barker DL, Jencks WP (1969). "Pig liver esterase. Physical properties." Biochemistry 8(10);3879-89. PMID: 4981346

Bertram69: Bertram J, Krisch K (1969). "Hydrolysis of vitamin A acetate by unspecific carboxylesterases from liver and kidney." Eur J Biochem 11(1);122-6. PMID: 5353595

BURCH54: BURCH J (1954). "The purification and properties of horse liver esterase." Biochem J 58(3);415-26. PMID: 13208632

Horgan69: Horgan DJ, Stoops JK, Webb EC, Zerner B (1969). "Carboxylesterases (EC 3.1.1). A large-scale purification of pig liver carboxylesterase." Biochemistry 8(5);2000-6. PMID: 5785220

Malhotra66: Malhotra OP (1966). "Specificity of goat intestinal esterase." Biochem. Z. 346 386-402.

Mentlein84: Mentlein R, Schumann M, Heymann E (1984). "Comparative chemical and immunological characterization of five lipolytic enzymes (carboxylesterases) from rat liver microsomes." Arch Biochem Biophys 234(2);612-21. PMID: 6208846

Runnegar69: Runnegar MT, Scott K, Webb EC, Zerner B (1969). "Carboxylesterases (EC 3.1.1). Purification and titration of ox liver carboxylesterase." Biochemistry 8(5);2013-8. PMID: 5785222

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
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