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MetaCyc EC 3.1.1.1 -- carboxylesterase

Parent Class: EC-Numbers 3 -- Hydrolases 3.1 -- Acting on ester bonds 3.1.1 -- Carboxylic ester hydrolases

Synonyms: ali-esterase, B-esterase, monobutyrase, procaine esterase, vitamin A esterase, butyryl esterase, carboxyesterase, carboxylate esterase, carboxylic esterase, methylbutyrate esterase, triacetin esterase, carboxyl ester hydrolase, butyrate esterase, methylbutyrase, α-carboxylesterase, propionyl esterase, nonspecific carboxylesterase, esterase D, esterase B, esterase A, serine esterase, carboxylic acid esterase, cocaine esterase

Systematic Name: carboxylic-ester hydrolase

Unification Links: BRENDA:3.1.1.1 , ENZYME:3.1.1.1 , IUBMB-ExplorEnz:3.1.1.1

Reaction:
a carboxylic ester + H2O → an alcohol + a carboxylate + H+

Unofficial Reactions:
all-trans-retinyl palmitate + H2O → all-trans-retinol + palmitate + H+ ,
all-trans-retinyl palmitate + H2O → a retinol + palmitate + H+ ,
methyl (indol-3-yl)acetate + H2O → indole-3-acetate + methanol + H+ ,
a methyl jasmonate + H2O → a jasmonic acid + methanol + H+ ,
salicyl-6-hydroxy-2-cyclohexene-on-oyl + H2O → 6-hydroxy-2-cyclohexen-one-carboxylate + salicyl alcohol + H+ ,
an all-trans-retinyl ester + H2O → all-trans-retinol + a long-chain fatty acid + H+ ,
1-O-methylsalicylate + H2O → salicylate + methanol + H+

Enzymes and Genes:
pimeloyl-[acp] methyl ester esterase : bioH ( Escherichia coli K-12 substr. MG1655 )
carboxylesterase 3 : CES3 ( Homo sapiens )
liver carboxylesterase 1 : CES1 ( Homo sapiens )

Summary:
Wide specificity. The enzymes from microsomes also catalyse the reactions of EC 3.1.1.2 (arylesterase), EC 3.1.1.5 (lysophospholipase), EC 3.1.1.6 (acetylesterase), EC 3.1.1.23 (acylglycerol lipase), EC 3.1.1.28 (acylcarnitine hydrolase), EC 3.1.2.2 (palmitoyl-CoA hydrolase), EC 3.5.1.4 (amidase) and EC 3.5.1.13 (aryl-acylamidase). Also hydrolyses vitamin A esters.

Citations: [Augusteyn69, Barker69, Bertram69, BURCH54, Horgan69, Mentlein84, Runnegar69, Malhotra66]


References

Augusteyn69: Augusteyn RC, de Jersey J, Webb EC, Zerner B (1969). "On the homology of the active-site peptides of liver carboxylesterases." Biochim Biophys Acta 171(1);128-37. PMID: 4884138

Barker69: Barker DL, Jencks WP (1969). "Pig liver esterase. Physical properties." Biochemistry 8(10);3879-89. PMID: 4981346

Bertram69: Bertram J, Krisch K (1969). "Hydrolysis of vitamin A acetate by unspecific carboxylesterases from liver and kidney." Eur J Biochem 11(1);122-6. PMID: 5353595

BURCH54: BURCH J (1954). "The purification and properties of horse liver esterase." Biochem J 58(3);415-26. PMID: 13208632

Horgan69: Horgan DJ, Stoops JK, Webb EC, Zerner B (1969). "Carboxylesterases (EC 3.1.1). A large-scale purification of pig liver carboxylesterase." Biochemistry 8(5);2000-6. PMID: 5785220

Malhotra66: Malhotra OP (1966). "Specificity of goat intestinal esterase." Biochem. Z. 346 386-402.

Mentlein84: Mentlein R, Schumann M, Heymann E (1984). "Comparative chemical and immunological characterization of five lipolytic enzymes (carboxylesterases) from rat liver microsomes." Arch Biochem Biophys 234(2);612-21. PMID: 6208846

Runnegar69: Runnegar MT, Scott K, Webb EC, Zerner B (1969). "Carboxylesterases (EC 3.1.1). Purification and titration of ox liver carboxylesterase." Biochemistry 8(5);2013-8. PMID: 5785222


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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 42:D459-D471 2014
Page generated by SRI International Pathway Tools version 18.5 on Sun Dec 21, 2014, biocyc14.