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Synonyms: MurE synthetase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine synthetase, uridine diphospho-N-acetylmuramoylalanyl-D-glutamyllysine synthetase, UPD-MurNAc-L-Ala-D-Glu:L-Lys ligase, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:L-lysine γ-ligase (ADP-forming)

Systematic Name: UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate:L-lysine γ-ligase (ADP-forming)

Unification Links: BRENDA:6.3.2.7, ENZYME:6.3.2.7, IUBMB-ExplorEnz:6.3.2.7

Reaction:
UDP-N-acetyl-α-D-muramoyl-L-alanyl-D-glutamate + L-lysine + ATP → UDP-N-acetyl-α-D-muramoyl-L-alanyl-γ-D-glutamyl-L-lysine + ADP + phosphate + H⁺

Enzymes and Genes:
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase: murE ( Thermotoga maritima )
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--lysine ligase: murE ( Staphylococcus aureus )

Summary:
Involved in the synthesis of a cell-wall peptide. This enzyme adds L-lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—2,6-diaminopimelate ligase, adds meso-diaminopimelate instead.

Citations: [vanHeijenoort01]

References

vanHeijenoort01: van Heijenoort J (2001). "Recent advances in the formation of the bacterial peptidoglycan monomer unit." Nat Prod Rep 18(5);503-19. PMID: 11699883