Parent Class:

EC-Numbers → 6 -- Ligases → 6.3 -- Forming carbon-nitrogen bonds → 6.3.2 -- Acid--amino-acid ligases (peptide synthases)

Synonyms: pantothenate synthetase (ambiguous), pantoate—β-alanine ligase (ambiguous)

Systematic Name: (R)-pantoate:β-alanine ligase (ADP-forming)

Unification Links: BRENDA:6.3.2.44, ENZYME:6.3.2.44, IUBMB-ExplorEnz:6.3.2.44

Reaction:
(R)-pantoate + β-alanine + ATP → (R)-pantothenate + ADP + phosphate + H⁺

Summary:
The enzyme, characterized from the archaeon Methanosarcina mazei, is involved in the biosynthesis of (R)-pantothenate. It is different from EC 6.3.2.1, the AMP-forming pantoate—β-alanine ligase found in bacteria and eukaryota.

Citations: [Ronconi08]

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References

Ronconi08: Ronconi S, Jonczyk R, Genschel U (2008). "A novel isoform of pantothenate synthetase in the Archaea." FEBS J 275(11);2754-64. PMID: 18422645

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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