Parent Class:

EC-Numbers → 6 -- Ligases → 6.2 -- Forming carbon-sulfur bonds → 6.2.1 -- Acid--thiol ligases

Synonyms: acyl-CoA synthetase (GDP-forming), acyl coenzyme A synthetase (guanosine diphosphate forming)

Systematic Name: carboxylic acid:CoA ligase (GDP-forming)

Unification Links: BRENDA:6.2.1.10, ENZYME:6.2.1.10, IUBMB-ExplorEnz:6.2.1.10

Reaction:
a carboxylate + coenzyme A + GTP → an acyl-CoA + GDP + phosphate

Citations: [Rossi64]

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References

Rossi64: Rossi, C. R., Gibson, D.M. (1964). "Activation of fatty acids by a guanosine triphosphate-specific thiokinase from liver mitochondria." J Biol Chem 239;1694-9. PMID: 14213337

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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