Parent Class:

EC-Numbers → 6 -- Ligases → 6.1 -- Forming carbon-oxygen bonds → 6.1.1 -- Ligases forming aminoacyl-tRNA and related compounds

Synonyms: prolyl-tRNA synthetase, prolyl-transferRNA synthetase, prolyl-transfer ribonucleate synthetase, proline translase, prolyl-transfer ribonucleic acid synthetase, prolyl-s-RNA synthetase, prolinyl-tRNA ligase

Systematic Name: L-proline:tRNA^Pro ligase (AMP-forming)

Unification Links: BRENDA:6.1.1.15, ENZYME:6.1.1.15, IUBMB-ExplorEnz:6.1.1.15

Reaction:
tRNA^Pro + L-proline + ATP → L-prolyl-[tRNA^Pro] + AMP + diphosphate

Unofficial Reactions:
tRNA^Pro + L-alanine + ATP → L-alanyl-[tRNA^Pro] + AMP + diphosphate

Enzymes and Genes:
proline—tRNA ligase: proS ( Escherichia coli K-12 substr. MG1655 )

Citations: [Norton64, Peterson65]

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References

Norton64: Norton SJ (1964). "Purification and properties of the prolyl RNA synthetase of Escherichia coli." Arch Biochem Biophys 106;147-52. PMID: 14217147

Peterson65: Peterson PJ, Fowden L (1965). "Purification, properties and comparative specificities of the enzyme prolyl-transfer ribonucleic acid synthetase from Phaseolus aureus and Polygonatum multiflorum." Biochem J 97(1);112-24. PMID: 16749091

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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