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Synonyms: Sol5 (ambiguous), SPS (ambiguous), solanapyrone synthase (bifunctional enzyme: prosolanapyrone II oxidase/prosolanapyrone III cyclosiomerase)

Systematic Name: prosolanapyrone-III:(–)-solanapyrone A isomerase

Unification Links: BRENDA:5.5.1.20, ENZYME:5.5.1.20, IUBMB-ExplorEnz:5.5.1.20

Reaction:
prosolanapyrone III → solanapyrone A

Summary:
The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone in some fungi. The bifunctional enzyme catalyses the oxidation of prosolanapyrone II and the subsequent Diels Alder cycloisomerization of the product prosolanapyrone III to solanapyrone A (cf. EC 1.1.3.42, prosolanapyrone II oxidase).

Citations: [Katayama98, Katayama08, Kasahara10]

References

Kasahara10: Kasahara K, Miyamoto T, Fujimoto T, Oguri H, Tokiwano T, Oikawa H, Ebizuka Y, Fujii I (2010). "Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani." Chembiochem 11(9);1245-52. PMID: 20486243

Katayama08: Katayama K, Kobayashi T, Chijimatsu M, Ichihara A, Oikawa H (2008). "Purification and N-terminal amino acid sequence of solanapyrone synthase, a natural Diels-Alderase from Alternaria solani." Biosci Biotechnol Biochem 72(2);604-7. PMID: 18256508

Katayama98: Katayama K, Kobayashi T, Oikawa H, Honma M, Ichihara A (1998). "Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction." Biochim Biophys Acta 1384(2);387-95. PMID: 9659400