Parent Class:

EC-Numbers → 5 -- Isomerases → 5.3 -- Intramolecular oxidoreductases → 5.3.99 -- Other intramolecular oxidoreductases

Synonyms: thromboxane synthase, (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A₂-isomerase

Systematic Name: (5Z,13E)-(15S)-9α,11α-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase

Unification Links: BRENDA:5.3.99.5, ENZYME:5.3.99.5, IUBMB-ExplorEnz:5.3.99.5

Reaction:
prostaglandin H₂ → thromboxane A₂

Unofficial Reactions:
prostaglandin H₃ → thromboxane A₃,
prostaglandin H₁ → thromboxane A₁,
prostaglandin H₂ → 12S-HHTrE + malondialdehyde

Enzymes and Genes:
thromboxane-A synthase: TBXAS1 ( Homo sapiens )

Summary:
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H₂ into thromboxane A₂.

Citations: [Ullrich83, Shen86]

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References

Shen86: Shen RF, Tai HH (1986). "Immunoaffinity purification and characterization of thromboxane synthase from porcine lung." J Biol Chem 261(25);11592-9. PMID: 3745158

Ullrich83: Ullrich V, Haurand M (1983). "Thromboxane synthase as a cytochrome P450 enzyme." Adv Prostaglandin Thromboxane Leukot Res 11;105-10. PMID: 6221511

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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