Parent Class:

EC-Numbers → 4 -- Lyases → 4.6 -- Phosphorus-oxygen lyases → 4.6.1 -- Phosphorus-oxygen lyases

Synonyms: monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, 1-phosphatidylinositol phosphodiesterase, 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming), 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)

Systematic Name: 1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)

Unification Links: BRENDA:4.6.1.13, ENZYME:4.6.1.13, IUBMB-ExplorEnz:4.6.1.13

Supersedes EC number: 3.1.4.10

Reaction:
a 1-phosphatidyl-1D-myo-inositol → a 1,2-diacyl-sn-glycerol + D-myo-inositol 1,2-cyclic phosphate

Enzymes and Genes:
1-phosphatidylinositol phosphodiesterase: plcA ( Bacillus cereus )

Summary:
This enzyme is bacterial. Activity is also found in animals, but this activity is due to the presence of EC 3.1.4.11, phosphoinositide phospholipase C.

Citations: [Friedel67, Allan74, Michell75, Low77, Irvine82, Henner88]

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References

Allan74: Allan D, Michell RH (1974). "Phosphatidylinositol cleavage catalysed by the soluble fraction from lymphocytes. Activity at pH5.5 and pH7.0." Biochem J 142(3);591-7. PMID: 4377210

Friedel67: Friedel RO, Brown JD, Durell (1967). "Monophosphatidyl inositol inositolphosphohydrolase in guinea-pig brain." Biochim Biophys Acta 144(3);684-6. PMID: 4294905

Henner88: Henner DJ, Yang M, Chen E, Hellmiss R, Rodriguez H, Low MG (1988). "Sequence of the Bacillus thuringiensis phosphatidylinositol specific phospholipase C." Nucleic Acids Res 16(21);10383. PMID: 3194218

Irvine82: Irvine RF (1982). "The enzymology of stimulated inositol lipid turnover." Cell Calcium 3(4-5);295-309. PMID: 6297738

Low77: Low MG, Finean JB (1977). "Release of alkaline phosphatase from membranes by a phosphatidylinositol-specific phospholipase C." Biochem J 167(1);281-4. PMID: 588258

Michell75: Michell RH, Allan D (1975). "Inositol cyclis phosphate as a product of phosphatidylinositol breakdown by phospholipase C (Bacillus cereus)." FEBS Lett 53(3);302-4. PMID: 236918

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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