Parent Class:

EC-Numbers → 4 -- Lyases → 4.3 -- Carbon-nitrogen lyases → 4.3.2 -- Lyases acting on amides, amidines, etc

Synonyms: btrG (gene name), γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase (5-oxoproline producing)

Systematic Name: γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase (5-oxo-L-proline producing)

Unification Links: BRENDA:4.3.2.6, ENZYME:4.3.2.6, IUBMB-ExplorEnz:4.3.2.6

Reaction:
γ-L-glutamyl-butirosin B → butirosin B + 5-oxo-L-proline

Enzymes and Genes:
γ-L-glutamyl-butirosin B γ-glutamyl cyclotransferase: btrG ( Niallia circulans )

Summary:
The enzyme catalyses the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the α-amine of the terminal L-glutamate of the side chain, releasing it as the cyclic 5-oxoproline.

Citations: [Llewellyn07]

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References

Llewellyn07: Llewellyn NM, Li Y, Spencer JB (2007). "Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain." Chem Biol 14(4);379-86. PMID: 17462573

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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