Parent Class:

EC-Numbers → 4 -- Lyases → 4.3 -- Carbon-nitrogen lyases → 4.3.2 -- Lyases acting on amides, amidines, etc

Synonyms: scoD (gene name), mmaD (gene name)

Systematic Name: (3R)-3-[(carboxylmethyl)amino]fatty acid glycine-lyase ((2E)-unsaturated fatty acyl-[acyl-carrier protein]-forming)

Unification Links: BRENDA:4.3.2.11, ENZYME:4.3.2.11, IUBMB-ExplorEnz:4.3.2.11

Reaction:
(2E)-unsaturated fatty acyl-[acp] + glycine + H₂O → a (3R)-3-[(carboxylmethyl)amino]fatty acid + acyl-carrier protein + 2 H⁺

Unofficial Reactions:
crotonyl-[acp] + glycine + H₂O → (R)-3-[(carboxylmethyl)amino]butanoate + acyl-carrier protein + 2 H⁺

Enzymes and Genes:
(2E)-unsaturated fatty acyl-[acp] glycyltransferase [multifunctional]: scoD ( Streptomyces coeruleorubidus )

Summary:
The enzyme, found in some actinobacterial species, participates in the biosynthesis of isonitrile-containing lipopeptides. It catalyzes both the transfer of a glycine moiety and the release of the product from the acyl-carrier protein.

Citations: [Harris17, Harris18]

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References

Harris17: Harris NC, Sato M, Herman NA, Twigg F, Cai W, Liu J, Zhu X, Downey J, Khalaf R, Martin J, Koshino H, Zhang W (2017). "Biosynthesis of isonitrile lipopeptides by conserved nonribosomal peptide synthetase gene clusters in Actinobacteria." Proc Natl Acad Sci U S A 114(27);7025-7030. PMID: 28634299

Harris18: Harris NC, Born DA, Cai W, Huang Y, Martin J, Khalaf R, Drennan CL, Zhang W (2018). "Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase." Angew Chem Int Ed Engl 57(31);9707-9710. PMID: 29906336

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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