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Synonyms: ornithine cyclase, ornithine cyclase (deaminating), L-ornithine ammonia-lyase (cyclizing)

Systematic Name: L-ornithine ammonia-lyase (cyclizing; L-proline-forming)

Unification Links: BRENDA:4.3.1.12, ENZYME:4.3.1.12, IUBMB-ExplorEnz:4.3.1.12

Reaction:
L-ornithine → L-proline + ammonium

Enzymes and Genes:
arginine dihydrolase/ornithine cyclodeaminase: agrE ( Nostoc sp. PCC 7120 = FACHB-418 )
ornithine cyclodeaminase: arcB ( Agrobacterium tumefaciens )
ornithine cyclodeaminase: arcB ( Clostridium sporogenes )

Summary:
Requires NAD⁺. The enzyme is a member of the μ-crystallin protein family [Goodman04]. The reaction is stimulated by the presence of ADP or ATP and is inhibited by O₂ [Muth74].

Citations: [Costilow71, Espineda99, Alam04]

References

Alam04: Alam S, Wang SC, Ruzicka FJ, Frey PA, Wedekind JE (2004). "Crystallization and X-ray diffraction analysis of ornithine cyclodeaminase from Pseudomonas putida." Acta Crystallogr D Biol Crystallogr 60(Pt 5);941-4. PMID: 15103146

Costilow71: Costilow RN, Laycock L (1971). "Ornithine cyclase (deaminating). Purification of a protein that converts ornithine to proline and definition of the optimal assay conditions." J Biol Chem 246(21);6655-60. PMID: 4399881

Espineda99: Espineda CE, Linford AS, Devine D, Brusslan JA (1999). "The AtCAO gene, encoding chlorophyll a oxygenase, is required for chlorophyll b synthesis in Arabidopsis thaliana." Proc Natl Acad Sci U S A 96(18);10507-11. PMID: 10468639

Goodman04: Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA, Wedekind JE (2004). "Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family." Biochemistry 43(44);13883-91. PMID: 15518536

Muth74: Muth WL, Costilow RN (1974). "Ornithine cyclase (deaminating). II. Properties of the homogeneous enzyme." J Biol Chem 249(23);7457-62. PMID: 4373469