Parent Class:

EC-Numbers → 4 -- Lyases → 4.2 -- Carbon-oxygen lyases → 4.2.3 -- Acting on phosphates

Synonyms: VoTPS2, VoTPS7

Systematic Name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, valerena-4,7(11)-diene-forming)

Unification Links: BRENDA:4.2.3.139, ENZYME:4.2.3.139, IUBMB-ExplorEnz:4.2.3.139

Reaction:
(2E,6E)-farnesyl diphosphate → valerena-4,7(11)-diene + diphosphate

Enzymes and Genes:
valerena-4,7(11)-diene synthase: TPS2 ( Valeriana officinalis )

Summary:
Isolated from the plant Valeriana officinalis (valerian). Note that due to a different numbering system the product is also known as valerena-1,10-diene.

Citations: [Pyle12, Yeo12]

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References

Pyle12: Pyle BW, Tran HT, Pickel B, Haslam TM, Gao Z, Macnevin G, Vederas JC, Kim SU, Ro DK (2012). "Enzymatic synthesis of valerena-4,7(11)-diene by a unique sesquiterpene synthase from the valerian plant (Valeriana officinalis)." FEBS J 279(17);3136-46. PMID: 22776156

Yeo12: Yeo YS, Nybo SE, Chittiboyina AG, Weerasooriya AD, Wang YH, Gongora-Castillo E, Vaillancourt B, Buell CR, Dellapenna D, Celiz MD, Jones AD, Wurtele ES, Ransom N, Dudareva N, Shaaban KA, Tibrewal N, Chandra S, Smillie T, Khan IA, Coates RM, Watt DS, Chappell J (2012). "Functional identification of valerena-1,10-diene synthase, a terpene synthase catalyzing a unique chemical cascade in the biosynthesis of biologically active sesquiterpenes in Valeriana officinalis." J Biol Chem 288(5);3163-73. PMID: 23243312

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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