Parent Class:

EC-Numbers → 4 -- Lyases → 4.2 -- Carbon-oxygen lyases → 4.2.2 -- Acting on polysaccharides

Synonyms: pectate exo-lyase, exopectic acid transeliminase, exopectate lyase, exopolygalacturonic acid-trans-eliminase, PATE, exo-PATE, exo-PGL, exopolygalacturonate lyase (ambiguous), pelW (gene name), pelX (gene name)

Systematic Name: (1→4)-α-D-galacturonan reducing-end-disaccharide-lyase

Unification Links: BRENDA:4.2.2.9, ENZYME:4.2.2.9, IUBMB-ExplorEnz:4.2.2.9

Reaction:
(1,4-α-D-galacturonosyl)_(n+m) → (1,4-α-D-galacturonosyl)_(n) + 4-(4-deoxy-α-D-galact-4-enuronosyl)-D-galacturonate

Unofficial Reactions:
an unsaturated pectate trisaccharide → 4-deoxy-L-threo-hex-4-enopyranuronate + 4-(4-deoxy-α-D-galact-4-enuronosyl)-D-galacturonate

Enzymes and Genes:
exopolygalacturonate lyase W: pelW ( Dickeya dadantii 3937 )

Summary:
The enzyme catalyses the eliminative cleavage of an unsaturated disaccharide from the reducing end of homogalacturonan (the backbone of smooth regions of pectate, also known as de-esterified pectin).

Citations: [MacMillan64, Shevchik99, Shevchik99a]

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References

MacMillan64: MacMillan JD, Vaughn RH (1964). "Purification and properties of a polygalacturonic acid-trans-eliminase produced by Clostridium multifermentans." Biochemistry 3;564-72. PMID: 14188174

Shevchik99: Shevchik VE, Kester HC, Benen JA, Visser J, Robert-Baudouy J, Hugouvieux-Cotte-Pattat N (1999). "Characterization of the exopolygalacturonate lyase PelX of Erwinia chrysanthemi 3937." J Bacteriol 181(5);1652-63. PMID: 10049400

Shevchik99a: Shevchik VE, Condemine G, Robert-Baudouy J, Hugouvieux-Cotte-Pattat N (1999). "The exopolygalacturonate lyase PelW and the oligogalacturonate lyase Ogl, two cytoplasmic enzymes of pectin catabolism in Erwinia chrysanthemi 3937." J Bacteriol 181(13);3912-9. PMID: 10383957

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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