| Parent Class: | EC-Numbers → 4 -- Lyases → 4.1 -- Carbon-carbon lyases → 4.1.99 -- Other carbon-carbon lyases |
Synonyms: pvcA (gene name)
Systematic Name: L-tyrosine:D-ribulose-5-phosphate lyase (isonitrile-forming)
Unification Links: BRENDA:4.1.99.24, ENZYME:4.1.99.24, IUBMB-ExplorEnz:4.1.99.24
Enzymes and Genes:
L-tyrosine isonitrile synthase:
pvcA (
Xenorhabdus nematophila ATCC 19061
)
L-tyrosine isonitrile synthase:
pvcA (
Pseudomonas aeruginosa
)
Summary:
The enzymes from the bacteria
Pseudomonas aeruginosa and
Xenorhabdus nematophila are involved in the biosynthesis of
paerucumarin and
rhabduscin, respectively. According to the proposed mechanism, the enzyme forms an imine intermediate composed of linked
L-tyrosine and
D-ribulose 5-phosphate, followed by loss of the phosphate group and formation of a β-keto imine and enol-keto tautomerization. This is followed by a C-C bond cleavage, the release of
hydroxyacetone, and a retro aldol type reaction that releases
formaldehyde and forms the final product
[Chang17]. cf.
EC 4.1.99.25, L-tryptophan isonitrile synthase.
Citations: [ClarkePearson08, Drake08]
References
Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 28.5 (software by SRI International) on Mon Mar 31, 2025, BIOCYC18.
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