Parent Class:

EC-Numbers → 4 -- Lyases → 4.1 -- Carbon-carbon lyases → 4.1.3 -- Oxo-acid-lyases

Synonyms: D-3-hydroxyaspartate aldolase

Systematic Name: 3-hydroxy-D-aspartate glyoxylate-lyase (glycine-forming)

Unification Links: BRENDA:4.1.3.41, ENZYME:4.1.3.41, IUBMB-ExplorEnz:4.1.3.41

Reaction:
(3S)-3-hydroxy-D-aspartate = glycine + glyoxylate,
(3R)-3-hydroxy-D-aspartate = glycine + glyoxylate

Enzymes and Genes:
D 3-hydroxyaspartate aldolase: dhaa ( Paracoccus denitrificans IFO 13301 )

Summary:
A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Paracoccus denitrificans IFO 13301, is strictly D-specific as to the α-position of the substrate, but accepts both the threo and erythro forms at the β-position. The erythro form is a far better substrate (about 100 fold). The enzyme can also accept D-allothreonine, D-threonine, D-erythro-3-phenylserine and D-threo-3-phenylserine. Different from EC 4.1.3.14, L-erythro-3-hydroxyaspartate aldolase. Requires a divalent cation, such as Mg2+, Mn2+ or Co2+.

Citations: [Liu03]

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References

Liu03: Liu JQ, Dairi T, Itoh N, Kataoka M, Shimizu S (2003). "A novel enzyme, D-3-hydroxyaspartate aldolase from Paracoccus denitrificans IFO 13301: purification, characterization, and gene cloning." Appl Microbiol Biotechnol 62(1);53-60. PMID: 12835921

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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