| Parent Class: | EC-Numbers → 4 -- Lyases → 4.1 -- Carbon-carbon lyases → 4.1.3 -- Oxo-acid-lyases |
Synonyms: 2-methylisocitrate lyase, MICL, (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase
Systematic Name: (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate pyruvate-lyase (succinate-forming)
Unification Links: BRENDA:4.1.3.30, ENZYME:4.1.3.30, IUBMB-ExplorEnz:4.1.3.30
Reaction:
(2R,3S)-2-methylisocitrate ↔ succinate + pyruvate
Enzymes and Genes:
2-methylisocitrate lyase:
prpB (
Escherichia coli K-12 substr. MG1655
)
2-methylcitrate lyase:
prpB (
Cupriavidus necator
)
2-methylisocitrate lyase:
prpB (
Salmonella enterica enterica serovar Typhimurium
)
Summary:
The enzyme acts on threo-Ds-2-methylisocitrate, but not on threo-Ds-isocitrate, threo-DL-isocitrate or erythro-Ls-isocitrate.
Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 28.5 (software by SRI International) on Mon Mar 31, 2025, BIOCYC14B.
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