| Parent Class: | EC-Numbers → 4 -- Lyases → 4.1 -- Carbon-carbon lyases → 4.1.1 -- Carboxy-lyases |
Synonyms: phenylpyruvate carboxy-lyase, phenylpyruvate carboxy-lyase (phenylacetaldehyde-forming)
Systematic Name: 3-phenyl-2-oxopropanoate carboxy-lyase (phenylacetaldehyde-forming)
Unification Links: BRENDA:4.1.1.43, ENZYME:4.1.1.43, IUBMB-ExplorEnz:4.1.1.43
Reaction:
3-phenyl-2-oxopropanoate + H+ → phenylacetaldehyde + CO2
Enzymes and Genes:
2-oxo acid decarboxylase:
ARO10 (
Saccharomyces cerevisiae
)
phenylpyruvate decarboxylase:
pdc (
Aromatoleum aromaticum
)
phenylpyruvate decarboxylase:
ipdC (
Azospirillum brasilense
)
phenylpyruvate decarboxylase:
ppdcα,
ppdcβ (
Streptomyces virginiae
)
pyruvate decarboxylase 3:
PDC6 (
Saccharomyces cerevisiae
)
pyruvate decarboxylase 2:
PDC5 (
Saccharomyces cerevisiae
)
pyruvate decarboxylase 1:
PDC1 (
Saccharomyces cerevisiae
)
Summary:
The enzyme from the bacterium
Azospirillum brasilense also acts on some other substrates, including
(indol-3-yl)pyruvate, with much lower efficiently. However, it only possesses classical Michaelis-Menten kinetics with
3-phenyl-2-oxopropanoate (phenylpyruvate). Aliphatic 2-oxo acids longer that
2-oxohexanoate are not substrates. cf
EC 4.1.1.74, indolepyruvate decarboxylase.
Citations: [Asakawa68, Spaepen07]
References
Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 28.5 (software by SRI International) on Sat Mar 29, 2025, BIOCYC15.
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