Parent Class:

EC-Numbers → 4 -- Lyases → 4.1 -- Carbon-carbon lyases → 4.1.1 -- Carboxy-lyases

Synonyms: uroporphyrinogen III decarboxylase, porphyrinogen carboxy-lyase, porphyrinogen decarboxylase, uroporphyrinogen-III carboxy-lyase

Systematic Name: uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)

Unification Links: BRENDA:4.1.1.37, ENZYME:4.1.1.37, IUBMB-ExplorEnz:4.1.1.37

Reaction:
uroporphyrinogen-III + 4 H⁺ → coproporphyrinogen III + 4 CO₂

Unofficial Reactions:
uroporphyrinogen-I + 4 H⁺ → coproporphyrinogen I + 4 CO₂

Enzymes and Genes:
uroporphyrinogen decarboxylase: hemE ( Escherichia coli K-12 substr. MG1655 )
uroporphyrinogen III decarboxylase: hemE ( Bacillus subtilis subtilis 168 )
uroporphyrinogen decarboxylase: UROD ( Homo sapiens )
uroporphyrinogen decarboxylase: Urod ( Mus musculus )
uroporphyrinogen decarboxylase: UROD ( Nicotiana tabacum )
uroporphyrinogen decarboxylase: hemE ( Cereibacter sphaeroides )

Summary:
Acts on a number of porphyrinogens.

Citations: [MAUZERALL58, Tomio70]

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References

MAUZERALL58: MAUZERALL D, GRANICK S (1958). "Porphyrin biosynthesis in erythrocytes. III. Uroporphyrinogen and its decarboxylase." J Biol Chem 232(2);1141-62. PMID: 13549492

Tomio70: Tomio JM, Garcia RC, San Martin de Viale LC, Grinstein M (1970). "Porphyrin biosynthesis. VII. Porphyrinogen carboxy-lyase from avian erythrocytes. Purification and properties." Biochim Biophys Acta 198(2);353-63. PMID: 4984554

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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