Parent Class:

EC-Numbers → 3 -- Hydrolases → 3.7 -- Acting on carbon-carbon bonds → 3.7.1 -- In ketonic substances

Systematic Name: 1-(2,6-dihydroxypyridin-3-yl)-4-(methylamino)butan-1-one hydrolase

Unification Links: BRENDA:3.7.1.19, ENZYME:3.7.1.19, IUBMB-ExplorEnz:3.7.1.19

Reaction:
2,6-dihydroxypseudooxynicotine + H₂O → 2,6-dihydroxypyridine + 4-methylaminobutanoate + H⁺

Enzymes and Genes:
2,6-dihydroxypseudooxynicotine hydrolase: DHPONH ( Paenarthrobacter nicotinovorans )

Summary:
The enzyme, characterized from the soil bacterium Paenarthrobacter nicotinovorans, participates in nicotine degradation.

Citations: [Gherna65, Sachelaru05]

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References

Gherna65: Gherna RL, Richardson SH, Rittenberg SC (1965). "The bacterial oxidation of nicotine. VI. The metabolism of 2,6-dihydroxypseudooxynicotine." J Biol Chem 1965;240(9);3669-74. PMID: 5835946

Sachelaru05: Sachelaru P, Schiltz E, Igloi GL, Brandsch R (2005). "An alpha/beta-fold C--C bond hydrolase is involved in a central step of nicotine catabolism by Arthrobacter nicotinovorans." J Bacteriol 187(24);8516-9. PMID: 16321959

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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