Parent Class:

EC-Numbers → 3 -- Hydrolases → 3.5 -- Acting on carbon-nitrogen bonds, other than peptide bonds → 3.5.1 -- In linear amides

Synonyms: peptidoglutaminase I, peptideglutaminase, peptidoglutaminase

Systematic Name: peptidyl-L-glutamine amidohydrolase

Unification Links: BRENDA:3.5.1.43, ENZYME:3.5.1.43, IUBMB-ExplorEnz:3.5.1.43

Reaction:
a [protein] C-terminal L-glutamine + H₂O → a [protein] C-terminal L-glutamate + ammonium + H⁺

Summary:
Specific for the hydrolysis of the γ-amide of glutamine substituted at the α-amino group, e.g., glycyl-L-glutamine, N-acetyl-L-glutamine and L-leucylglycyl-L-glutamine.

Citations: [Kikuchi71]

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References

Kikuchi71: Kikuchi M, Hayashida H, Nakano E, Sakaguchi K (1971). "Peptidoglutaminase. Enzymes for selective deamidation of gamma-amide of peptide-bound glutamine." Biochemistry 10(7);1222-9. PMID: 4928623

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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