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Synonyms: proteinase Ia, Pycnoporus coccineus aspartic proteinase, Trametes acid proteinase

Unification Links: BRENDA:3.4.23.30, ENZYME:3.4.23.30, IUBMB-ExplorEnz:3.4.23.30

Supersedes EC numbers: 3.4.4.17, 3.4.23.6

Reaction:
protein + H₂O → 2 peptide + 2 H⁺

Enzymes and Genes:
rhizopuspepsin I: RCAPI ( Rhizopus microsporus chinensis )

Summary:
This enzyme is similar to pepsin A, but narrower, cleaving only three bonds in the B chain of insulin: Ala¹⁴-|-Leu, Tyr¹⁶-|-Leu, and Phe²⁴-|-Phe

Citations: [Tomoda64, Tsuru69, Ichishima80]

References

Ichishima80: Ichishima, E., Kumagai, H, Tomoda, K. (1980). "Substrate specificity of carboxyl proteinase from Pycnoporus coccineus, a wood-deteriorating fungus." Curr. Microbiol.

Tomoda64: Tomoda, K., Shimazono, H. (1964). "Acid protease produced by Trametes sanguinea a wood-destroying fungus. Part I. Purification and crystallization of the enzyme." Agric. Biol. Chem.

Tsuru69: Tsuru, D., Hattori, A., Tsuji, H., Yamamoto, T, Fukumoto, J. (1969). "Studies on mold proteases. Part II. Substrate specificity of acid protease of Rhizopus chinensis." Agric. Biol. Chem.