Parent Class:

EC-Numbers → 3 -- Hydrolases → 3.4 -- Acting on peptide bonds (peptide hydrolases) → 3.4.23 -- Aspartic endopeptidases

Synonyms: parapepsin I, pig gelatinase

Unification Links: BRENDA:3.4.23.2, ENZYME:3.4.23.2, IUBMB-ExplorEnz:3.4.23.2

Supersedes EC number: 3.4.4.2

Reaction:
protein + H₂O → 2 peptide + 2 H⁺

Summary:
This enzyme catalyzes degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than that of pepsin A; does not cleave at Phe¹-Val, Gln⁴-His or Gly²³-Phe .

Citations: [Ryle70]

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References

Ryle70: Ryle, A.P. (1970). "The porcine pepsins and pepsinogens." Methods Enzymol.

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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