Parent Class:

EC-Numbers → 3 -- Hydrolases → 3.4 -- Acting on peptide bonds (peptide hydrolases) → 3.4.22 -- Cysteine endopeptidases

Synonyms: actinidin, Actinidia anionic protease, proteinase A₂ of Actinidia chinensis

Unification Links: BRENDA:3.4.22.14, ENZYME:3.4.22.14, IUBMB-ExplorEnz:3.4.22.14

Reaction:
kiwellin + H₂O → kissper + kith

Summary:
This enzyme is similar to that of papain.

From the kiwi fruit or Chinese gooseberry ( Actinidia chinesis). In peptidase family C1 (papain family).

Citations: [Baker80, Kamphuis85, Baker87]

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References

Baker80: Baker EN, Boland MJ, Calder PC, Hardman MJ (1980). "The specificity of actinidin and its relationship to the structure of the enzyme." Biochim Biophys Acta 616(1);30-4. PMID: 7002215

Baker87: Baker, E.N., Drenth, J. (1987). "The thiol proteases: stucture and mechanism." In: Jurnak, F.A. and McPherson, A. (Eds.), Biological Macromolecules and Assemblies: Active Sites of Enzymes, vol. 3, John Wiley and Sons, New York.

Kamphuis85: Kamphuis IG, Drenth J, Baker EN (1985). "Thiol proteases. Comparative studies based on the high-resolution structures of papain and actinidin, and on amino acid sequence information for cathepsins B and H, and stem bromelain." J Mol Biol 182(2);317-29. PMID: 3889350

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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