Parent Class:

EC-Numbers → 3 -- Hydrolases → 3.4 -- Acting on peptide bonds (peptide hydrolases) → 3.4.17 -- Metallocarboxypeptidases

Synonyms: ACE-2, ACE2, hACE2, angiotensin converting enzyme 2, angiotensin converting enzyme-2, Tmem27

Unification Links: BRENDA:3.4.17.23, ENZYME:3.4.17.23, IUBMB-ExplorEnz:3.4.17.23

Reaction:
angiotensin-2 + H₂O → angiotensin-1-7 + L-phenylalanine

Unofficial Reactions:
angiotensin-1 + H₂O → angiotensin 1-9 + L-leucine

Enzymes and Genes:
angiotensin-converting enzyme 2: ACE2 ( Homo sapiens )

Summary:
A transmembrane glycoprotein with an extracellular catalytic domain. Angiotensin-converting enzyme 2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates [Lambert08]. Catalytic efficiency is 400-fold higher with angiotensin-2 as a substrate than with angiotensin-1. Angiotensin-converting enzyme 2 also efficiently hydrolyzes des-Arg9-bradykinin, but it does not hydrolyze bradykinin [Vickers02]. In peptidase family M2.

Citations: [Towler04]

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References

Lambert08: Lambert DW, Hooper NM, Turner AJ (2008). "Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system." Biochem Pharmacol 75(4);781-6. PMID: 17897633

Towler04: Towler P, Staker B, Prasad SG, Menon S, Tang J, Parsons T, Ryan D, Fisher M, Williams D, Dales NA, Patane MA, Pantoliano MW (2004). "ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis." J Biol Chem 279(17);17996-8007. PMID: 14754895

Vickers02: Vickers C, Hales P, Kaushik V, Dick L, Gavin J, Tang J, Godbout K, Parsons T, Baronas E, Hsieh F, Acton S, Patane M, Nichols A, Tummino P (2002). "Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase." J Biol Chem 277(17);14838-43. PMID: 11815627

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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