Parent Class:

EC-Numbers → 3 -- Hydrolases → 3.4 -- Acting on peptide bonds (peptide hydrolases) → 3.4.11 -- Aminopeptidases

Synonyms: aminopeptidase III, aminopeptidase yscI, leucine aminopeptidase IV, yeast aminopeptidase I

Unification Links: BRENDA:3.4.11.22, ENZYME:3.4.11.22, IUBMB-ExplorEnz:3.4.11.22

Reaction:
peptide with an N-terminal L-amino acid + H₂O → a proteinogenic amino acid + peptide

Summary:
Release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates.

Belongs to peptidase family M18.

Citations: [Johnson41, Metz76, Chang89, Oda96]

---

References

Chang89: Chang YH, Smith JA (1989). "Molecular cloning and sequencing of genomic DNA encoding aminopeptidase I from Saccharomyces cerevisiae." J Biol Chem 264(12);6979-83. PMID: 2651436

Johnson41: Johnson, M.J. (1941). "Isolation and properties of a pure yeast polypeptidase." J. Biol. Chem.

Metz76: Metz G, Rohm KH (1976). "Yeast aminopeptidase I. Chemical composition and catalytic properties." Biochim Biophys Acta 429(3);933-49. PMID: 5147

Oda96: Oda MN, Scott SV, Hefner-Gravink A, Caffarelli AD, Klionsky DJ (1996). "Identification of a cytoplasm to vacuole targeting determinant in aminopeptidase I." J Cell Biol 132(6);999-1010. PMID: 8601598

---

Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
Page generated by Pathway Tools version 28.5 (software by SRI International) on Sat Mar 29, 2025, BIOCYC14.