Parent Class:

EC-Numbers → 3 -- Hydrolases → 3.1 -- Acting on ester bonds → 3.1.3 -- Phosphoric monoester hydrolases

Synonyms: fructose-2,6-bisphosphatase, D-fructose-2,6-bisphosphate 2-phosphohydrolase

Systematic Name: β-D-fructose-2,6-bisphosphate 2-phosphohydrolase

Unification Links: BRENDA:3.1.3.46, ENZYME:3.1.3.46, IUBMB-ExplorEnz:3.1.3.46

Reaction:
β-D-fructose 2,6-bisphosphate + H₂O → β-D-fructofuranose 6-phosphate + phosphate

Enzymes and Genes:
fructose-2,6-bisphosphatase TIGAR: TIGAR ( Homo sapiens )
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2: PFKFB2 ( Homo sapiens )
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4: PFKFB4 ( Homo sapiens )
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3: PFKFB3 ( Homo sapiens )
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1: PFKFB1 ( Homo sapiens )

Summary:
The enzyme copurifies with EC 2.7.1.105 6-phosphofructo-2-kinase. (cf. EC 3.1.3.54 fructose-2,6-bisphosphate 6-phosphatase).

Citations: [vanSchaftingen82]

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References

vanSchaftingen82: van Schaftingen E, Davies DR, Hers HG (1982). "Fructose-2,6-bisphosphatase from rat liver." Eur J Biochem 124(1);143-9. PMID: 6282585

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Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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