Parent Class:

EC-Numbers → 3 -- Hydrolases → 3.1 -- Acting on ester bonds → 3.1.3 -- Phosphoric monoester hydrolases

Systematic Name: [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]-phosphate phosphohydrolase

Unification Links: BRENDA:3.1.3.44, ENZYME:3.1.3.44, IUBMB-ExplorEnz:3.1.3.44

Reaction:
an [acetyl-CoA carboxylase]-O-phospho-L-serine + H₂O → an [acetyl CoA-carboxylase] L-serine + phosphate

Summary:
Simultaneously dephosphorylates and activates EC 6.4.1.2 acetyl-CoA carboxylase. Acts similarly on EC 1.1.1.88, hydroxymethylglutaryl-CoA reductase, EC 2.4.1.1, phosphorylase, EC 2.4.1.11, glycogen(starch) synthase, and dephosphorylates phosphoprotamine and 4-nitrophenyl phosphate. Not identical to EC 3.1.3.17, [phosphorylase] phosphatase or EC 3.1.3.43, [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase.

Citations: [Krakower81]

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References

Krakower81: Krakower GR, Kim KH (1981). "Purification and properties of acetyl-CoA carboxylase phosphatase." J Biol Chem 256(5);2408-13. PMID: 6257718

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Report Errors or Provide Feedback
Please cite the following article in publications resulting from the use of MetaCyc: Caspi et al, Nucleic Acids Research 46(D1):D633-D639 2018
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